It’s that time of week, ladies and gentlemen! We will breakdown each of the outside matchups, as well as my 10 favorite matchups out of the slot. Then, below the charts in this article, I break down my absolute favorite matchups by price in DFS, as well as likely ownership in seasonal formats. This article is critical for seasonal and daily players, as this will help you gain a competitive advantage when setting your lineups.

Remember, the No. 1 wide receiver doesn’t always matchup against the No. 1 cornerback. This isn’t a game of Madden! Seriously, it’s not!

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Now, here are my 10 favorite matchups in the slot in Week 16.

Elite

DeAndre Hopkins vs. Rasul Douglas

This could be the biggest mismatch between any wide receiver and cornerback on the entire Week 16 slate. Douglas has allowed the most yards in coverage over the last three weeks, while Hopkins has the third-most receiving yards in that same span.*...