NFL Best Bets for Divisional Round Saturday 2026: Picks, Predictions & Player Props

The NFL Divisional Round kicks off with the #1 seeds coming off their byes - the Denver Broncos hosting the Buffalo Bills and the Seattle Seahawks hosting the San Francisco 49ers. With a rematch of last year’s postseason and a divisional rivalry, we’re here to make them even more exciting with our NFL best bets for Divisional Round Saturday.

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NFL Picks, Predictions & Best Bets for the Divisional Round 

It’s been since 2021 that the #1 seeds have been featured on the Saturday of the Divisional Round, and that comes to the dismay of fans in Buffalo. We say that because Josh Allen suffered seemingly every injury possible in the Bills' Wild Card win over the Jacksonville Jaguars.

Thankfully for our sake, he still came through for our NFL expert picks! He did so by both finding the endzone with his legs and cashing Buffalo’s money line, so we’re more than happy to target their game with our NFL best bets for Divisional Round Saturday. It’s also going to be quite the clash of styles.

A Bills vs. Broncos game features a very porous defense in Buffalo against arguably the best defense in Denver (Houston Texans fans will certainly refute that). So, while the Broncos aren’t considered a truly dominant #1 seed in the eyes of many, you’re going to find that we’re still going to target them with our NFL best bets for Divisional Round Saturday.
 

Best NFL Divisional Round Predictions

As for making NFL picks for the later game, it’s one that we’ll be targeting for the third time this season. We saw 49ers vs. Seahawks games both in the very FIRST week of the regular season and the very LAST one. That recent clash was for the #1 seed in the NFC, which was also on a Saturday night.

Seattle held Christian McCaffrey and company to a measly three points, so they, too, would have something to say about our previous comment about the Denver defense. It’s an interesting dynamic with this NFC West rivalry, as the 49ers were once a team feared for their defense; that is no longer the case with the lack of Fred Warner and Nick Bosa.

Speaking of San Francisco injuries, we also won’t be including George Kittle in our NFL best bets for Divisional Round Saturday, as the superstar TE suffered a torn Achilles tendon last weekend. Again, given the stout Seattle defense, it’s going to be difficult to trust any 49ers offensive player, even if CMC did some through for a best bet last weekend.

So, when it comes to this rivalry as part of our NFL best bets for Divisional Round Saturday, you’re instead going to see a Seahawks star offensive weapon.

Bills vs. Broncos Best Bet: RJ Harvey Over 47.5 Rushing Yards (-122 at Novig)

It’s only fitting to kick things off with the first game of the day. Many fans may not remember that these AFC squads met in the Wild Card Round last season, as the Bills bullied the Broncos to the tune of a 31-7 victory. Of course, a lot has changed since then, which includes Denver drafting an RB out of UCF in the second round of the 2025 NFL Draft.

That would be RJ Harvey, who has become the bell cow of the backfield, given the long-term JK Dobbins injury. We’re certainly not going to compare him to the likes of the aforementioned Christian McCaffrey, but he still makes the cut for our NFL best bets for Divisional Round Saturday. Again, the Bills' defense is suspect at best.

That’s about as kindly as we can put it - Buffalo allowed the fifth-most rushing yards per game during the regular season. As for Wild Card Weekend, they allowed the second-most. Denver QB Bo Nix has certainly taken a step in the right direction, but he’s not the gunslinger Broncos fans watched when Peyton Manning joined the team.

If anything, Nix also enjoys using his legs as well. For a true flyer, consider the QB to score an anytime TD, but we’re going to kick off our NFL best bets for Divisional Round Saturday with RJ Harvey over 47.5 rushing yards (-122 at Novig).
 

49ers vs. Seahawks Best Bet: Jaxon Smith-Njigba Anytime TD (-101 at Novig)

As promised, we’re going to be targeting a Seahawks superstar. When we said that, you likely could have guessed who that would be - JSN. Jaxon Smith-Njigba has quickly become a large piece of the debate in terms of the very best WR in the NFL. Therefore, you’re sure to see several ways to add him into NFL best bets for Divisional Round Saturday.

However, with how much he’s exploded this season, his lines for yards and receptions aren’t as appealing in terms of value. That said, you could still stick with yards - JSN has torched the 49ers for 110, 124, and 84 yards in his past three games against them. Furthermore, he’s had 10 catches on 11 targets, nine grabs on 13 targets, and six on eight targets in those matchups.

Even still, it’s time for him to find the end zone against his division rival, hence the focus of our NFL best bets for Divisional Round Saturday. We’ve already noted the 49ers' diminished defense, which is why we saw them allow 29 passing TDs this season. Even without that factor, JSN simply gets enough volume for this pick.

It may not be the most unique way to approach this NFC West rivalry, but we’re adding to our NFL best bets for Divisional Round Saturday with Jaxon Smith-Njigba to score an anytime TD (-101 at Novig).

Best NFL Player Prop Bets & Other Picks for Divisional Round Saturday

As much as we love our NFL picks above, we’ve also got some other popular NFL Divisional Round player props at Novig Sportsbook for you:

Passing Yards:

• Josh Allen: Over 215.5 (-119) vs. Under 215.5 (-119)
• Sam Darnold: Over 235.5 (-120) vs. Under 235.5 (-114)

Rushing Yards:

• James Cook: Over 80.5 (+116) vs. Under 80.5 (-127)
• Christian McCaffrey: Over 55.5 (-119) vs. Under 55.5 (-119)

Receiving Yards:

• Courtland Sutton: Over 49.5 (-119) vs. Under 49.5 (-119)
• Jaxon Smith-Njigba: Over 90.5 (-115) vs. Under 90.5 (-116)

Anytime TD Scorer: 

• RJ Harvey: -121
• Kenneth Walker: +111
• Bo Nix: +321

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