We have 10 games for Wednesday, May 13, 2026, MLB main slate. We have a very fun slate tonight with elite pitchers everywhere you turn, including Jacob Misiorowski, Dylan Cease, and Shohei Ohtani are taking the mound. To maximize your edge, make sure you are utilizing our MLB DFS optimizer and updated hitter projections. Before locking in your rosters, dive into the latest coaching analysis and monitor ownership trends to see where the field is gravitating.

Top Projected MLB DFS Pitchers

The pitching landscape tonight is defined by strikeout potential and favorable matchup metrics rather than pure ace status.

Jacob Misiorowski (MIL) at SD

If you haven't heard, Jacob Misiorowski throws really, really hard. Not only does he throw hard, but he leads all of major league baseball in strikeout rate amongst qualified pitchers. He faces off a Padres offense ranking 23rd or worse in OPS, wOBA, and wRC+ while striking out nearly 23% of the time against right-handed pitching. His upside is truly unmatched when he's generating whiffs, which he's often doing.

Want the rest of the top plays for todays pitching staff? Unlock the full MLB DFS Playbook for every elite arm and strikeout projection to win your contests today!

Best MLB DFS Stacks Today

Targeting specific splits and regression candidates is the key to identifying the MLB DFS best lineup today.

Athletics (vs. St. Louis Cardinals)

The Athletics have a slate-leading 5.4 implied runs and face off against a very inconsistent pitcher in Matthew Liberatore. Lefties have crushed him this year with a .349 ISO, .302 xISO, .438 wOBA, and .418 xwOBA and righties numbers under the hood look good as he's allowed a .178 xISO and .345 xwOBA.

This is the best ballpark per Baseball Savant to hit in this year and it's warm, which means the ball will travel even more. The power upside the Athletics have between Nick Kurtz, Shea Langeliers, Tyler Soderstrom, Brent Rooker, Zack Gelof have is ELITE.

Looking for the best contrarian stacks to gain leverage? Check out the MLB DFS Playbook to see which low-owned teams are ready to break the slate!

Best Value Plays For DraftKings and FanDuel

To fit high-end bats and top-tier pitching, you must identify hitters in favorable split matchups.

Josh Naylor (1B, SEA)

There's no reason that the Mariners as a whole are this cheap, but alas, they still are. Lance McCullers has been hit hard by left-handed hitters allowing a .233 ISO and .379 wOBA. Naylor has a .341 AVG and .836 OPS over his last 10 games.

Ready to crush your contests? Get every elite pick, positional breakdown, and the heart of the order in the full MLB DFS Playbook only at Fantasy Alarm!

MLB DFS Optimal Lineup For Today

Success on a full Tuesday slate depends on pairing high-upside arms with offensive exposure to pitchers showing significant underlying regression. Below is a sample MLB DFS optimal lineup for DraftKings based on todays metrics and the 7:07 PM ET Main Slate.

Pos Player Team Opponent Salary Proj. Draft%
Pivot{{player.position.alias}} Pivot {{player.player.name}} {{player.player.team.abbr}} {{player.player.opp.abbr}} {{getValue(lineup,player) | money}} {{getDraft(lineup,player)}}
{{totalValue(lineup) | money}}