Friday night (+1 early game) baseball is here, and our MLB best bets today for 5/22 are built around one of the best pitching slates of the week. Jacob deGrom returns to the mound in Los Angeles, Gerrit Cole takes the ball in New York for the first time, and the weekend kicks off with an Apple TV matinee to warm things up. We've paired our top MLB picks with today's GUARANTEED 10x Novig Sportsbook promo code bonus!

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⚾ MLB Picks, Predictions & Best Bets Today, 5/22

Friday's card has an excellent blend of marquee arms and hitter-friendly environments that give our MLB best bets today plenty to work with. The evening wave kicks off just after 6:30 PM ET and runs all the way through a West Coast nightcap after 10 PM ET. Logan Gilbert, Kevin Gausman and Payton Tolle are among the starters worth tracking for strikeout markets, and the Gerrit Cole comeback narrative in the Bronx will dominate the conversation. 

Check our MLB expert picks for the full breakdown across every game. The prop markets on a Friday like this tend to be sharp from the jump as books price in weekend money, and while that makes finding value on game lines and totals a little trickier, it also creates real opportunity in the player markets for those willing to dig. Let's get into our MLB best bets today for 5/22!
 

 

 

🔥 Rockies vs. Diamondbacks Best Bet: YRFI - Yes Run First Inning (-121 at Novig)

There were just seven games yesterday, and we were still able to go 2-for-2 with our MLB predictions here. So, let’s start it in the same way that we did and have done far more often than not - with a potential very early cash. The Rockies vs. Diamondbacks series is the first target for our MLB best bets today, even with yesterday’s game.

It was a surprising 2-1 finish, but we expect far more runs today. We expect them to come primarily from Arizona against Tomoyuki Sugano, but as always, we don’t care who crosses the plate as long as it’s in the first inning. Corbin Carroll is as consistent as it gets, and Sugano is among the worst in the MLB in so many categories.

Rather than rattling off a list of 10+ stats, we’ll just let you know that he’s a prime candidate for early runs allowed, and even Colorado has big bats like Mickey Moniak and Hunter Goodman. So, let’s get our MLB best bets today started with a Rockies vs. Diamondbacks YRFI (-121 at Novig).

🔥 Nationals vs. Braves Best Bet: Matt Olson Over 2.5 Hits+Runs+RBI (+104 at Novig)

We paired our YRFI pick yesterday with a batter prop, so let’s stay on brand to keep the good times rolling into the weekend. We also cashed this prop pick just two games ago when it was at 1.5, thinking the line was wrong, and you can now see why. First and foremost, Miles Mikolas is always great for helping us hit our MLB best bets today.

If he gets removed from the starting rotation before the season's end, we won’t be surprised. His HR/FB ratio is the absolute worst in the entire league, and while it’s teammate Jake Irvin that is far worse in the 1st inning, we won’t care when this pick lands. In fact, we won’t even be worried later on, given Washington’s terrible bullpen.

This feels like a 1-swing-cash via home run, so we love adding to our MLB best bets today with Matt Olson over 2.5 hits+runs+RBI (+104 at Novig).
 

 

 

⚾ Best MLB Prop Bets & Other Picks Today, 5/22

Beyond our featured MLB predictions today, Friday's card has individual markets worth targeting across every time slot. Here are some of the most popular MLB player props for today at Novig Sportsbook:

Home Runs:

Strikeouts (Over/Under):

Total Bases (Over/Under):

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