It’s been a while since the three straight NFC Championship Games of the early 1990s that featured the San Francisco 49ers and Dallas Cowboys, but the two are back at it this Sunday. Brock Purdy’s MVP campaign has his team as one of the Super Bowl favorites while Dak Prescott and company are in a weak NFC East, so a playoff preview isn’t out of the question. So, let’s make the most of this matchup with our best 49ers vs. Cowboys predictions for Week 10.
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🔥 49ers vs. Cowboys Predictions for NFL Week 10, Sunday, 11/15
Seeing as the last time that Dallas was in an NFC Championship Game was against the 49ers, we need to focus on our NFL expert picks for this Sunday rather than looking ahead to the postseason. That’s even more true given the inconsistent play that we just saw against a reeling Indianapolis Colts team, even if George Pickens was out.
It’s going to have plenty of fans fading Dallas with their 49ers vs. Cowboys predictions, especially given that San Francisco is one of the most feared teams in the NFC and NFL in general. This matchup has primetime potential, and when it comes to the advantageous matchup, it is undoubtedly the San Francisco passing game against the Dallas secondary.
That’s why the health of Mike Evans looms large, not to mention the Keenan Allen trade and how Brandon Aiyuk has been making headlines since his drama resurfaced prior to last weekend’s games. We have a ton to consider here, so let’s see how it shapes the best bet from our top 49ers vs. Cowboys predictions for Week 10!
🏅 49ers vs. Cowboys Expert Pick: George Kittle Anytime TD (49% at Novig)
Given that we have a matchup that includes the Dallas defense, it’s no surprise that we have a high game total for this clash. In fact, it may end up being the highest that we see all season, as the oddsmakers are suggesting nearly 60 points! Therefore, the focus of our 49ers vs. Cowboys predictions for Sunday correlates to a game featuring plenty of points.
It was Dallas star WR CeeDee Lamb who cashed an anytime TD for us against the Colts, but now it’s time to pick on their defense like every opponent has been doing this season. We mentioned the health of Mike Evans, and since we have to operate as if he is out once again (for now), we love this spot for the San Francisco starting TE. Yes, even with the aging Keenan Allen now a target.
He’s matchup-proof to begin with, but plenty of 49ers vs. Cowboys picks will be focused on him given the Dallas D. With no Evans on the field, his target share stocks only go up, and he just had seven in a game that was a blowout from the jump. Since Dallas has the offensive firepower to keep pace in this game, a competitive one should lead to even more targets.
As Brock Purdy continues to build his MVP case, the best bet from our 49ers vs. Cowboys predictions for Week 10 can help it, as we’re locking in a George Kittle anytime TD (49% at Novig).
👀 How To Watch 49ers vs. Cowboys NFL Week 10
With this being the featured matchup in the late afternoon window, make sure that you check out how to watch 49ers vs. Cowboys NFL Week 10:
- Where: AT&T Stadium, Arlington, TX
- When: 4:25 PM ET on 11/15
- Watch on TV: FOX
- Where to stream: YouTube TV, Fubo, Hulu + Live TV
🔢 49ers vs. Cowboys Odds, Spreads, Total & Betting Lines
You’re also going to want more than just the line for our best bet, and below, you’ll see the latest 49ers vs. Cowboys odds for Sunday:
- Point Spread: San Francisco 49ers -3.5 (-110) vs. Dallas Cowboys +3.5 (-110)
- Money Line: San Francisco 49ers (-205) vs. Dallas Cowboys (+170)
- Game Total (Over/Under): Over 55.5 (-110) vs. Under 55.5 (-110)
🏉 49ers vs. Cowboys Injury Report & Latest News
- Mike Evans (DNP)
- Renardo Green (DNP)
- Deommodore Lenoir (DNP)
- Dre Greenlaw (LIMITED - rest)
- Siran Neal (LIMITED)
- Deebo Samuel (LIMITED)
- Upton Stout (LIMITED)
- C.J. West (LIMITED)
- Trent Williams (LIMITED - rest)
- Nate Hobbs (FULL)
- Christian McCaffrey (FULL)
- Demarcus Robinson (FULL)
- Alijah Clark (DNP)
- Donovan Ezeiruaku (DNP)
- Jake Ferguson (DNP)
- Tyler Goodson (DNP)
- P.J. Locke (DNP)
- Jonathan Mingo (DNP)
- Joey Porter (DNP)
- George Pickens (LIMITED)
- Juanyeh Thomas (LIMITED)
- KaVontae Turpin (LIMITED)
- Jonathan Bullard (FULL)
- Malik Hooker (FULL)
- Marist Liufau (FULL)
- Von Miller (FULL)
- Devin Moore (FULL)
- DeMarvion Overshown (FULL)
- Luke Schoonmaker (FULL)
- Brevyn Spann-Ford (FULL)
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