The 2026-27 college football season rolls on with an intriguing Friday night slate of games! It’s time to lock in our CFB best bets today before the action gets underway. Check out these CFB picks for Friday’s Week 11 college football slate on November 13th. Without further ado, let’s jump into this week’s top CFB predictions.

CFB Picks, Predictions & Best Bets: Friday, 11/13

Our CFB best bets today start with Pittsburgh hosting Florida State in an ACC matchup. Plus, Houston takes on Colorado in the Big 12. Check out more CFB picks below for the rest of Friday’s action. Good luck! 

 

 

 

Florida State vs. Pittsburgh Prediction: Friday, November 13th

Let’s kick off our CFB best bets today with an ACC matchup between Florida State and Pittsburgh. The home Panthers have a few key edges to win and cover the spread. Let’s back them to get it done on Friday night. 

Despite last week’s win, Florida State is still worth fading. The Seminoles barely beat Boston College, needing a late fourth-quarter touchdown to survive. They were previously 1-4 in conference play, including double-digit losses to Clemson and Louisville over the past month. 

Florida State is also in a poor situational spot. The Noles could easily be in for a letdown after last week’s win, which came right after firing head coach Mike Norvell. Don’t be surprised if they revert to the team that consistently underperformed against tougher competition. Plus, this will be FSU’s fourth road trip in five games. 

Conversely, Pittsburgh is coming off its bye week ahead of this matchup. The extra rest and prep could be huge for a team that needed a reset. The Panthers won their last game, but previously lost three straight in October. 

As for this game, Pitt’s defense should be a difference-maker. The Panthers rank 10th nationally in defensive success rate, 29th in total yards allowed per game, and 31st in points allowed per game. They’ve also allowed just 13.2 PPG across five home matchups against FBS opponents. 

Florida State, meanwhile, has struggled on defense. The Seminoles rank 121st in total yards allowed per game, 117th in defensive EPA/Play, and 102nd in defensive success rate. They’ve also allowed 31.0 PPG to FBS competition this year, ranking 103rd in the country. Pitt’s offense has been up and down this year, but this matchup is favorable. Plus, the bye week came at a good time for backup QB Holden Geriner to get more comfortable in the offense as he fills in for injured starter Mason Heintschel.  

Some betting trends also back Pittsburgh tonight. Over the past four seasons, Pitt is 6-3 against the spread as a home conference favorite. It’s also 8-4 ATS when favored in ACC play over the last three seasons.

Houston vs. Colorado Prediction: Friday, November 13th

Let’s focus now on a Big 12 matchup as Houston visits Colorado on Friday night. The Cougars should win this game as 9.5-point road favorites. Instead of worrying about the spread, though, our CFB best bets today will center on the over/under. 

Houston features one of college football’s most potent offenses. The Cougs average 35.4 points per game and are 13th nationally in total offense. They also rank 10th in offensive EPA/Play and boast the 2nd-best offensive success rate in the country. 

Even on the road, Houston should score and move the ball well against Colorado’s shaky defense. The Buffaloes are allowing 30.0 PPG in conference play. They’ve especially struggled against the pass, ranking 100th nationally in passing yards allowed per game to FBS opponents and 98th in defensive EPA/Pass. 

Meanwhile, Houston’s defense has also struggled this year. The Cougs rank 125th in defensive EPA/Play and 117th in defensive success rate. Defending the pass has been the main issue, as the defense ranks 124th in EPA/Pass. 

Colorado, admittedly, doesn’t exactly have a trustworthy offense. However, Houston’s defensive struggles should bring out the best in the Buffs’ attack – especially at home. Plus, Colorado has scored at least 24 points in three of the last four games. Some of those performances came against better defenses than Houston’s unit. 

Take the over in this Big 12 matchup. The over is 3-1 in Colorado’s last four games, largely because of its improved offense. The total is set at 51.5 points, which is low for Houston’s games. Cougars games have seen at least 51 combined points scored in seven of nine contests. 

 

 

 

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