2026 NFL Week 10 Picks Straight Up, Odds & Spreads For All 14 Games

Welcome to our 2026 NFL Week 10 Picks Straight Up! Last week, we correctly predicted 14 out of 15 games, only missing Saints over Browns, which went to overtime and came down to a single point, PLUS we made our picks before Deshaun Watson was ruled out. I’d say that is a pretty good week. Let’s keep it up with another exciting NFL slate! 

So, without further ado, it is time to bring you our expert 2026 NFL Week 10 Picks Straight Up. Below, you will find my picks, some highlighted matchups, and the odds and spreads for every game this week.

2026 NFL Week 10 Picks Straight Up for All 14 Games

With Week 10 here, we have some great matchups on paper and four more teams on bye! The Chicago Bears, Denver Broncos, Philadelphia Eagles, and Tampa Bay Buccaneers get some much-needed rest this week, leaving 28/32 teams in the Week 10 schedule. In the following section, you will find my predictions, with the teams I anticipate coming away with a victory highlighted in bold. Odds are courtesy of BetMGM:

NFL Week 10 Picks Straight Up: Carolina Panthers ML (+118 at FanDuel Sportsbook)

It feels like you can never know what will happen in an NFC South game. There is not a single team over .500 in this division; each team has dealt with significant injuries, and two of the teams were sellers at the NFL trade deadline. It is worth noting that one of them is in this very matchup and is actually favored.

The Carolina Panthers have shown more from an eye test standpoint than the New Orleans Saints to me. They are getting healthier, with Mike Jackson, Jonathon Brooks, and Xavier Legette all returning to practice this week, Bryce Young has shown moments of brilliance in a fun offense, and the defense took a step in the right direction after parting ways with Ejiro Evero. Sure, they are coming off a loss to the Denver Broncos, but we are quick to forget that the Broncos have only dropped two games this season and are still elite on defense. That was anyone’s game up until the end, and things happened to fall in Denver’s favor.

Meanwhile, the New Orleans Saints are coming off an overtime victory where they just squeaked out a win against a Browns team starting their backup quarterback, Shedeur Sanders. Even in a winning effort, I was not entirely impressed with what the Saints showed on film. If I am given the option between an offense led by Tyler Shough and Audric Estime or Bryce Young and Chuba Hubbard, along with the weapons in the receiving game, I am likely going to take the Panthers group nine times out of ten. If the Panthers happened to win their Week 9 matchup, they would likely be favored here; so I am happy to take the slight discount with the Panthers on the road.

NFL Week 10 Picks Straight Up: Miami Dolphins ML (+170 at BetMGM Sportsbook)

Now THIS matchup is CINEMA: the 1-7 Miami Dolphins against the 2-7 Indianapolis Colts. Two teams in tank mode facing off. Oddly enough, I am a little shocked to see the Colts so clearly favored in this game, but I am sure that has to do with the quarterback situation. Yes, the Miami Dolphins are starting Kyle McCord, a second-year quarterback out of Syracuse who has yet to attempt a pass in the NFL. That being said, with a supporting cast made up of some ascending rookie receivers and Ollie Gordon in the run game, who has snatched the bell cow role from the rest of the RB room, I strangely think this offense can put up enough points against an underperforming Colts defense to steal a victory here. 

The Indianapolis Colts made it clear that they are onto 2027, selling off key players like Quinton Nelson, DeForest Buckner, Kennan Allen, and Josh Downs. Jonathan Taylor is checked out and has less of a workload, Daniel Jones does not look like the same player as he was in 2025, and their number one receiver is now Laquon Treadwell. Not exactly the most exciting team.

Meanwhile, the Dolphins have a sliver of hope, as there have been several bright spots on this team, especially on the defensive side of the ball. Chris Johnson and Jacob Rodriguez are some of the most electric rookies in the entire NFL, and defensive end Chop Robinson has emerged as a premier pass rusher, squarely in the top ten in quarterback pressures. Given how this team has been fighting and competing against more talented and proven teams, even in their losses, I would certainly back them to defeat a Colts team with no clear direction.

2026 NFL Week 10 Odds & Spreads For All 14 Games

We just unveiled our 2026 NFL Week 10 picks, and below are the spread odds for each matchup, provided by BetMGM Sportsbook:

How to bet on our Free Picks at BetMGM Sportsbook and Win $1,500 in Bonus Bets 'Guaranteed' 

If you want to make the most of our free picks, try signing up with BetMGM with our exclusive bonus code ALARM!

This welcome bonus is straightforward and inclusive, giving you the chance to place wagers on any matchup you like during NFL Week 10. A first bet up to $1,500 gets covered under code ALARM, and if that qualifying wager comes up short, the value returns not as one lump sum but as five separate $300 bonus bet credits instead, each valid for a full seven days:

Whatever you choose to bet, your bet is sweat-free! In other words, sit back, relax, and bet on anything when you become a new member with our BetMGM bonus code ALARM!