2026 NFL Week 10 Picks Against The Spread + NFL Week 10 Schedule Predictions

As the old saying goes, “Good teams win, great teams cover.” We are back for Week 10 with our picks against the spread! Yesterday was the NFL trade deadline, providing exciting moves like Kirk Cousins' triumphant return to Minnesota and Josh Downs rounding out the Chiefs' wide receiver room. Now over halfway through the NFL season, we have a better idea about each of these teams and who is separating themselves from the pack to make a run at the Lombardi Trophy. 

Below, we will be breaking down our NFL Week 10 Picks Against the Spread while also going through the NFL Week 10 schedule. So without further ado, let's dive in!

2026 NFL Week 10 Picks Against The Spread at DraftKings Sportsbook

With Week 10 here, we have just two teams on their bye week, leaving 28 of the 32 teams playing in 14 matchups across the league. In the following section, you will find my predictions, with my 2026 NFL Week 10 Picks Against the Spread in the right column. All lines are provided by DraftKings Sportsbook:

NFL Week 10 Picks Against The Spread: Minnesota Vikings +3.5 (-112 at BetMGM Sportsbook) 

I know that the Minnesota Vikings are on a two-game losing streak, but let us not forget how elite their defense is. The Vikings have only allowed 14.5 points per game (first in the NFL) and are second to only the Seattle Seahawks in yards allowed per game. Brian Flores is proving once again how valuable a defensive coach he is, and now the offensive side of the ball should help keep pace with the addition of quarterback Kirk Cousins.

Usually, I would have a little bit of caution when backing a quarterback joining a new team like this, but Kirk Cousins is no stranger to Kevin O’Connell and the Minnesota Vikings. In 2022, they helped lead the Vikings to a 13-4 record, with Cousins passing for over 4,500 yards en route to a Pro Bowl selection. The Vikings offense has been one of the least efficient in the league this season; even if he is not 2022 Kirk Cousins anymore, he should help kickstart the offense and provide a higher ceiling than before.

These two teams have already faced off back in Week One, and despite a potent passing game from Jordan Love, the Vikings still walked away with a 17-point victory. In this game, the Vikings only needed 239 total yards of offense. Now, once again without a reliable run game with Josh Jacobs out due to injury, it’ll be up to Love to carry the load. Even if he is able to come away with a win this time, I don’t think where these two teams are now is enough for me to justify a 3.5 spread against the team that won last time. The Vikings' defense is still elite, the offense is improving, and I am happy to take the Vikings spread here.

NFL Week 10 Picks Against The Spread: Baltimore Ravens -4 (-112 at BetMGM Sportsbook) 

Death. Taxes. And picking against the Los Angeles Chargers. It seems like the Chargers have completely run out of options. Mike McDaniel’s banishment to the booth did not help at all, and now both Justin Herbert and Ladd McConkey are banged up (again). The defense has at least been feisty at times, but after shipping off Daiyan Henley at the trade deadline and still without Derwin James, I do not think it is enough to carry this incompetent of an offense.

In my opinion, the spread is so close due to the introduction of a new quarterback behind center for the Baltimore Ravens in Jacoby Brissett. Brissett, however, has already been playing competitive football throughout the year with the Arizona Cardinals and now gets a more creative playcaller in Declan Doyle, a reliable run game with Derrick Henry, and an explosive weapon unlike anyone they had in Arizona with Zay Flowers. Brissett has had well over a week to get acclimated in this spot, and I like him to help the Ravens get a win here against the winless Chargers.

2026 NFL Week 10 Schedule & Predictions Featuring Commanders vs. Giants

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NFL Week 10 Lines & Las Vegas Odds Provided by DraftKings

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