NFL DFS Week 10 D/ST Picks 2026: Top DraftKings & FanDuel Defenses

Published Nov 13, 2026Updated Nov 13, 2026

Week 10 of the NFL is here, and we’re entering the “holiday” stretch of the season with Halloween behind us and both Thanksgiving and Christmas on the horizon. And this is the time of year we’re going to start experiencing some truly odd slates, with games on Wednesday and Friday for Week 12 (the week of Thanksgiving), and then we’ll start getting Saturday games and Christmas Day games in December.

All this is to say that we need to get used to smaller slates. Even smaller than this 10-game slate we have for Week 10! But we also have the return of the NFL playing in Europe as the New England Patriots and Detroit Lions are off the main slate this week for a tilt in Munich, Germany. Additionally, great defenses like the Chicago Bears and Denver Broncos get the week off. And surprisingly, the eight most expensive DSTs on DraftKings are all playing on the road. So Week 10 is a bit of a slippery slope with who we target, but I feel confident with the picks and analysis for Sunday’s games. Let’s dig into the NFL DFS Week 10 DST picks for your winning lineups on DraftKings and FanDuel!

NFL DFS Week 10 DST Picks

Los Angeles Rams – DraftKings: $3,800 | FanDuel: $4,500

The Arizona Cardinals enter Week 10 in rough shape. They already traded Jacoby Brissett to the Baltimore Ravens. Gardner Minshew has an elbow injury, and he’s now done for the season. And to make matters worse, Michael Wilson’s season is over due to a neck injury. So the organization is now turning to rookie quarterback Carson Beck in a tough NFC West matchup against the Los Angeles Rams.

The Cardinals are 9.5-point underdogs at home and they have an implied team total of just 15 points. And the Rams defensive line is now complete with Myles Garrett having returned from injury last week. In his return (and just his second game with the Rams), Garrett recorded three sacks and a forced fumble against the Washington Commanders.

The Rams have allowed a total of just 22 points in their last two games. And over their last three games, they’re allowing just 57.3 rushing yards per game, so they haven’t exactly been easy to run on. I think we can trust the Rams in this matchup to provide a good floor, but they also have the ceiling for double-digit fantasy points, and they correlate well with Kyren Williams.

Buffalo Bills – DraftKings: $3,500 | FanDuel: $4,600

I’m treading carefully with this recommendation, but I’ll never truly fade a DST going up against Geno Smith just in case Geno turns into a pumpkin during the matchup. But since their Bye week, the Bills DST has returned fantasy scores of 14 and 15 points against the likes of the Baltimore Ravens and Minnesota Vikings. But to be fair, Lamar Jackson got hurt on the first offensive play of the game for Baltimore, and we’re all aware of the quarterback woes the Vikings have dealt with the last few seasons.

But still, in those two games since Buffalo’s Bye week, they’ve allowed a total of 195 passing yards, 127 rushing yards, and 16 total points. The defense has forced six turnovers and collected six sacks.

This game does have one of the higher implied game totals (50.5 points), but the Bills are sizable 8.5-point favorites. But the Bills also frustrate opposing quarterbacks. On the year, opposing quarterbacks rank bottom five in completion percentage over expected (-3.0%) against this Buffalo defense. So it all boils down to how Geno Smith plays for the Jets because he comes with variance, but I’m willing to lean into that by targeting the Bills as a DST this week for our NFL DFS lineups.

Seattle Seahawks – DraftKings: $3,300 | FanDuel: $4,800

For what it’s worth, I do like the Houston Texans, who are just slightly more expensive than the Seahawks on both DraftKings and FanDuel. So if your gut is telling you to play them over Seattle, and you can afford them, by all means trust your gut.

But the Seattle Seahawks go on the road to take on the Las Vegas Raiders, and they get to give Fernando Mendoza the ultimate “Welcome to the NFL” treatment. The Raiders traded Kirk Cousins to Minnesota earlier this week, so Mendoza officially takes over as the team’s starting quarterback after being taken first overall in the latest NFL Draft.

But we do need to monitor the injury reports and the inactives list on Sunday. For Week 9, the Seahawks were without Leonard Williams, Brandon Pili, and Uchenna Nwosu. So if they’re available for this matchup, especially Williams, then we play Seattle with a little more conviction against a rookie quarterback making his first career start.

The Seahawks have been a bit of a nightmare matchup for quarterbacks and opposing offenses for most of the season. And it doesn’t help that the Raiders have struggled to run the ball as well. They’re second-worst in rushing yards per game on the year (71.3), and over their last three games that number drops to 55.7 rushing yards per game. They rank dead last in yards before contact per carry (0.62) and stuffed run rate (25.0%).

The Raiders truly are throwing Mendoza into the deep end and may ask a lot of him early on. If the Seahawks are a bit healthier than last week, then they’re good to go. But if inactives come out on Sunday and they’re missing some pieces on defense, then feel free to pivot to Houston against the Cleveland Browns.

Best NFL DFS DST Values for Week 10

Best DraftKings DST Value – Minnesota Vikings; $2,800

It’s a short week for the Vikings after playing on Monday Night Football in Week 9. However, I do like the price tag on DraftKings (not so much on FanDuel) for this NFC North matchup. This is no slam dunk, obviously, especially after we saw this defense give up 23 points to the Buffalo Bills just a few days ago. However, the Vikings were still able to collect four sacks in that game.

The Packers are playing much better of late after a sluggish start to the season. But I’m still of the mindset that they struggle with running the ball (68.2 rushing yards per game), so they’ll need to rely on a big performance from Jordan Love and Co.

The Vikings still top the charts among all 32 NFL teams in terms of blitz rate (70.1%), pressure rate (48.3%), and sack rate (10.7%), according to Sam Hoppen. And while the Packers offense has been on cruise control lately, the offensive line is still a concern. They rank 18^th in pressure rate allowed (38.9%), 26^th in quick pressure rate allowed (20.8%), and 27^th in average time to pressure (2.46 seconds), so it’s entirely feasible the Vikings can disrupt the offense’s flow in the matchup.

Best FanDuel DST Value – Atlanta Falcons; $3,600

You can certainly consider the Falcons on DraftKings if you need a little more salary relief. They’re available for $2,500 on that platform, but I can never pass up rostering the Vikings when they’re so affordable. But I secretly think the Falcons can surprise people with a potential upset on Sunday. The only problem with the Falcons is we never know which version of this team is going to show up.

When playing at home, the Falcons allow just 17.0 points per game and 308.5 yards per game to opposing offenses. On the road, they give up 28.6 points per game and 377.4 yards per game. For this home matchup against the Kansas City Chiefs, they’re surprisingly only three-point underdogs.

The Falcons don’t have the most proactive pass rush like the Vikings do. They rank just 28^th in blitz rate (23.5%), but they rank fifth in pressure rate (42.2%). And this is also the same team that beat the Green Bay Packers and handed the San Francisco 49ers their first loss of the season, so they certainly can pull off the upset against better teams.

Moreover, Patrick Mahomes has been getting a bit lucky with his passing totals. Per Steve Palazzolo, 67.4% of Mahomes’ passing yards have come after the catch, which is the most since 2010. His aDOT (average depth of target) is currently at 5.8 for the 2026 season, and that’s a number that has continuously dropped year-after-year. Moreover, in his last four games, he’s been under 5.0 air yards per attempt in four straight games entering this matchup. Per Doug Clawson, he’s the only quarterback in the last 20 years with under 5.0 air yards per attempt in four straight games with 30+ pass attempts.

So I’m buying into the Falcons, who surprisingly still have a pulse in the NFC South, but I don’t love that they go into this matchup without Jesse Bates, who was recently traded to the Jacksonville Jaguars. But overall, if I need to pay down for a DST on DraftKings or FanDuel, I can at least talk myself into the Falcons.

NFL DFS DST Fade for Week 10

Kansas City Chiefs – DraftKings: $3,200 | FanDuel: $4,700

This could blow up in my face, but as things stand Friday morning, I’m not loving the Chiefs on the road against the Atlanta Falcons. I think there are safer options, and there are certainly teams that offer a higher ceiling. It all boils down to what version of the Atlanta Falcons we get in this game. But in general, they have performed better at home this year.

The Chiefs' defense tends to regress on the road. Just one of their 14 sacks this year has come on the road. At home, they allow just 14.5 points per game and 248.2 yards per game to opposing offenses. When they’re on the road, those numbers inflate to 21.2 points per game and 367.5 yards per game. And while the Falcons are frustrating to roster and start for fantasy football, they do still have weapons on offense, and they have a good offensive line because Michael Penix has not taken a sack in his last three games.

This game is just giving me similar vibes to when we faded the San Francisco 49ers a few weeks ago when they played Atlanta in their barn. Atlanta handed them their first loss of the season, and a part of me believes the Falcons have a real chance to win this game as well. The matchup could get ugly, but at Kansas City’s price on DraftKings and FanDuel, I have a hard time buying into this as a “ceiling” game for them, so I’d rather invest elsewhere for a DST.

NFL DFS Week 10 DST Play of the Week

Jacksonville Jaguars – DraftKings: $4,000 | FanDuel: $4,900

You have to feel for the Tennessee Titans going up against a team that was very aggressive at the NFL Trade Deadline. The Jaguars acquired Jesse Bate III and Jordan Davis to bolster the defense. While both men have yet to practice this week, it’s entirely possible they’re able to make their debuts with their new team this weekend in Nashville.

Obviously, we know the Titans aren’t very good, and the Jags were already good defensively, and they just got better. Cam Ward enters Week 10 ranking 26^th in EPA/play (-0.06), and he’s 28^th in average depth of target (7.0 yards). Ward is averaging under 200 passing yards per game; he’s only thrown six touchdowns this year, and he’s turned the ball over in six consecutive games.

The Jaguars are the biggest favorites at 10.5 points for the Week 10 main slate, and the Titans come in with an implied team total of just 18 points. If the Jags officially get Bates and Davis for this matchup, then we should expect a little more line movement. But both players certainly raise the floor/ceiling for this DST’s fantasy production.