Looking for the best NFL TNF player prop picks for Week 2? The Lions and Bills both enter 1-0 for a Thursday night showdown that also doubles as the regular-season debut of Buffalo's new Highmark Stadium. Below, we break down our top Lions vs. Bills player props, complete with the lines and the matchup context behind each play.

Best NFL Thursday Night Football Player Prop Picks

Both of these teams opened the season in dramatic fashion, with Buffalo escaping Houston 36-31 and Detroit needing overtime to beat New Orleans 31-30. The last time these two met, back in December 2024, they combined for 90 points in a 48-42 Bills win, and the number on this one, 54.5, suggests the market expects more fireworks. Buffalo is currently a 4.5-point home favorite. Here are the props we like best for this one.

 

 

 

Lions vs. Bills Player Props: DJ Moore Over 4.5 Receptions

DJ Moore wasted no time making an impact in his Bills debut, catching 5 of a team-high 8 targets for 100 yards and a touchdown in the Week 1 win over Houston, highlighted by a 43-yard score. Reunited with head coach Joe Brady, who coached him to two 1,000-yard seasons in Carolina, Moore looked every bit like Josh Allen's new go-to option from the jump. He did take a late hit and spent some time in the medical tent, though he returned to finish the game, and there's been no indication he's in danger of missing Thursday's home opener. With that level of early chemistry and target share already established, clearing 4.5 receptions in Buffalo's second game looks very reasonable.

Lions vs. Bills Player Prop Bets: Jahmyr Gibbs Over 123.5 Rushing + Receiving Yards

Gibbs just turned in the best game of his career, carrying 29 times for 156 yards and adding five catches for 30 more in Detroit's overtime win over New Orleans, good for 186 yards from scrimmage and two touchdowns. That workload came after the Lions traded away David Montgomery this offseason and signed Gibbs to a three-year extension that made him the highest-paid running back in football, with Dan Campbell openly calling him the offense's bell cow. Campbell went a step further after the game, saying Gibbs is still not all the way there and that several more explosive runs were left on the field. With that level of investment and workload established in Week 1, clearing 123.5 yards from scrimmage again looks very attainable for Detroit's new focal point.

 

 

 

Thursday Night Football Player Props: Josh Allen Over 30.5 Pass Attempts

Allen and the Bills are walking into a game that projects as one of the highest-scoring on the Week 2 board, with the total sitting at 54.5, the largest number of the week. Detroit's defense just allowed 410 passing yards and three touchdowns to Tyler Shough in Week 1, a significant step down in competition from what Allen represents. Buffalo also has more to work with in the passing game than a year ago after adding DJ Moore, who opened his Bills career with 100 yards and a touchdown on a team-high eight targets. With this much firepower on both sides and a shootout-caliber number on the board, expecting Allen to push well past 30.5 attempts feels like the right side.

Lions vs. Bills Player Prop Bets: Jared Goff Under 35.5 Pass Attempts

Jahmyr Gibbs just turned in a career-high 29 carries and 34 total touches in Week 1, and Dan Campbell made it clear afterward that Detroit's new $67.5 million bell cow still has another level to give. With David Montgomery traded away this offseason and new offensive coordinator Drew Petzing building the offense around Gibbs, the Lions have every incentive to keep leaning on the ground game rather than asking Goff to throw it 39-plus times again as he did in Week 1's overtime win. A heavier dose of Gibbs, paired with a shorter, more efficient passing script, points to a lighter workload for Goff through the air. Staying under 35.5 attempts looks like the likely outcome if Detroit leans into its identity.

 

 

 

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