For the third time in four weeks, Josh Allen and the Buffalo Bills have a home game, and they’ve only had to go down the road to play the New York Jets so far. That’s quite a luxury to have, as is hosting a New Orleans Saints team with far lesser expectations. Even still, we’ve got our best Saints vs. Bills predictions to help find value.

Not only that, but you’ll also see why the current BetMGM Sportsbook promo code bonus for a chance to win a 15x boost to your bankroll can be perfect for your Saints vs. Bills picks.

Saints vs. Bills Predictions for NFL Week 4, Sunday 9/28

As mentioned, the Saints have far fewer expectations with Spencer Rattler under center rather than Josh Allen, and that couldn’t have been more evident this past weekend. New Orleans was down 38-3 to the Seattle Seahawks before halftime, ultimately losing 44-13.

With that comes the Saints vs. Bills odds that show Buffalo as the biggest favorite we may see the entire season. As 16.5-point favorites, it’s even worse than the look-ahead line of 14.5 points, and if it closes here, it will be the biggest underdog spot since Archie Manning took on Fran Tarkenton in 1975.

As lopsided a matchup as this is projected to be, that’s a monster spread to target. Therefore, the focus of our Saints vs. Bills predictions is elsewhere. 

 

 

 

Saints vs. Bills Best Bet: Keon Coleman Over 42.5 Receiving Yards (-115 at BetMGM)

Look, Josh Allen and the Bills could absolutely win this game by 20+ points, but this is still the NFL where anyone can beat anyone. Just ask the Green Bay Packers. That said, we’re still not going to pick the Saints to pull off an even bigger upset than the Cleveland Browns last weekend.

As if having the NFL’s easiest schedule wasn’t beneficial enough for Buffalo, they now get to take on this 0-3 team following a Thursday Night Football game, meaning extra rest. On top of that, when Josh Allen last faced the Saints, he threw four TD passes in a 31-6 beatdown.

That was before the team drafted Keon Coleman in the 2024 NFL Draft. It’s now time for him to look more like what we saw in Week 1, where he had 11 targets for eight catches, 112 yards, and a touchdown. Teams then started focusing on him more, but after Dalton Kincaid and Khalil Shakir's TDs last weekend, there is more to worry about.

We saw Seahawks QB Sam Darnold throw for two TD passes this past Sunday, and then he basically didn’t have to play the entire second half. The Saints are also one of just three teams to allow seven passing TDs this year, and only one team has allowed more, so finding the endzone could certainly be an approach as well.

However, red zone targets are not where the Florida State product has been getting most of the attention, so we see more value focusing on yardage. Therefore, the best bet from our Bills vs. Saints predictions is Keon Coleman over 42.5 receiving yards (-115 at BetMGM).
 

 

 

How To Watch Saints vs. Bills NFL Week 4

Josh Allen and Buffalo don’t even have to leave the eastern time zone but once this year (Houston), and as for how to watch Saints vs. Bills NFL Week 4, here are the details:

  • Where: Highmark Stadium, Orchard Park, NY
  • When: 1 PM ET on 9/28
  • Watch on TV: CBS
  • Where to stream: YouTubeTV, Fubo, Hulu + Live TV, Paramount+
     
 

 

Saints vs. Bills Odds, Spreads, Total & Betting Lines

As you’d expect, Buffalo is significantly favored, and you can see with the latest Saints vs. Bills odds for Sunday at BetMGM Sportsbook below:

 

 

Saints vs. Bills Injury Report & Latest News

As has been the case in Buffalo, defenders Matt Milano and Ed Oliver are easily their biggest concerns, so we can knock their side of the Saints vs. Bills injury news out first. Similarly in terms of defense, the biggest name of note in New Orleans is Chase Young. Potential blowout or not, monitor all Saints vs. Bills injury news and updates around the league with the Fantasy Alarm NFL injury report.
 

 

 

How To Bet On Saints vs. Bills at BetMGM Sportsbook & Claim Your $150 Bonus w/ Code ALARM

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When we say anything, that includes just picking a huge favorite. So, you could add to our Saints vs. Bills picks by getting Buffalo’s money line at 15/1 odds! That’s some incredible value, so be sure to sign up today using our exclusive BetMGM promo code ALARM!

 

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