There is virtually always some type of revenge game going on in the NFL these days, and the coast-to-coast clash on Monday Night Football provides exactly that to close out Week 12. Christian McCaffrey & the San Francisco 49ers host his former Carolina Panthers, and we’re here to add to it with our best Panthers vs. 49ers predictions for MNF.

We’ll add to any and all Panthers vs. 49ers picks with a guaranteed 10x Novig Sportsbook promo code bonus as well!

Panthers vs. 49ers Predictions for Monday Night Football, NFL Week 12

Believe it or not, both the Panthers and the 49ers have their eyes set on a playoff berth. However, they are both looking up at others in their respective divisions, so this is a pivotal MNF battle. That’s also why we want to have you covered with multiple angles, so be sure to enjoy our premium NFL best bets for Monday Night Football.

From an overall perspective, we fully expect Christian McCaffrey to get his revenge on the Panthers, even if he doesn’t have any ill will towards the franchise. He’s coming off a game in which his three total TDs fueled his team to 41 points, and given the added motivation, making him part of any Panthers vs. 49ers predictions is certainly warranted.

San Francisco fans should also be excited about the team getting healthier, and we’ll get more into that in just a moment. As for fans in Carolina, they should be excited about their future since it’s a rookie WR - Tetairoa McMillan - that just helped young QB Bryce Young have the best game of his career.

They’re going to need to repeat a similar performance to pull off quite a significant upset on the road in prime time, but them doing so is not the focus of our Panthers vs. 49ers predictions for MNF.

 

 

 

Panthers vs. 49ers Best Bet: Ricky Pearsall Over 39.5 Receiving Yards (-119 at Novig)

We mentioned San Francisco getting healthier, so let’s not waste any time expanding on that. After all, it certainly impacts any Panthers vs. 49ers picks this week. After missing six games with a toe injury, Brock Purdy made his return this past Sunday. So too did one of his weapons - Ricky Pearsall.

Both had been out since their late September game against the Arizona Cardinals, so it was only fitting that they returned against the same team. Although Brock Purdy threw for three TDs, the connection with Ricky Pearsall was not there like it normally is. That’s why we see value with the line the Panthers vs. 49ers odds are giving us.

George Kittle returned earlier than those two guys, but his being healthy helps take pressure off the outside WRs. We’ve seen teams capitalize on that against the Panthers in a big way. Just last Sunday, Drake London racked up 119 yards before both he and QB Michael Penix suffered knee injuries.

In each of the three games prior, Carolina allowed Chris Olave (thrown to by a rookie QB) to record 104 receiving yards, Romeo Doubs to have 91 receiving yards, and Khalil Shakir to have 88 receiving yards. We could likely have kept that going if the next game before those wasn’t against the New York Jets’ historically bad passing offense.

We know that last Sunday’s numbers will cause hesitation, but we still have Ricky Pearsall over 39.5 receiving yards (-119 at Novig) as the best bet from our Panthers vs. 49ers predictions.

 

 

 

How To Watch NFL Week 12 Monday Night Football

It’s a long trip for Carolina for this prime time game, and here’s how to watch Panthers vs. 49ers NFL Week 12 Monday Night Football: 

  • Where: Levi's Stadium, Santa Clara, CA
  • When: 8:15 PM ET on 11/24
  • Watch on TV: ESPN, ABC
  • Where to stream: ESPN+

 

 

 

Panthers vs. 49ers Odds, Spreads, Total & Betting Lines

CMC is expected to have little trouble getting revenge over his former team based on the latest Panthers vs. 49ers odds for MNF at Novig Sportsbook:

 

 

 

Panthers vs. 49ers Injury Report & Latest News

San Francisco getting healthier played a significant role in our best bet, so let’s start there regarding Panthers vs. 49ers injury news. Although the guys above have made their return, let’s not forget the long-term losses of Nick Bosa and Fred Warner.

As for Panthers vs. 49ers injury news in Carolina, as great as Tetairoa McMillan has been, the team would love to see Xavier Legette be 100% healthy. You can keep tabs on all of those names and so much more all season long by bookmarking the Fantasy Alarm NFL injury report.

 

 

 

How To Make Panthers vs. 49ers Picks At Novig Sportsbook & Claim Your $50 Bonus w/ Code ALARM

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You can use those Novig funds to make picks on anything, so you’ll be set up for more than just Panthers vs. 49ers picks. Well, that’s once you sign up today with our exclusive Novig MNF promo code ALARM!

 

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