After being featured on Thursday Night Football, Josh Allen and the Buffalo Bills have another high-profile matchup at home at Highmark Stadium. This time, they’re hosting Justin Herbert and the Los Angeles Chargers, who will be leaving LA for the first time this season. It’s just one of Week 3’s cross-country matchups, and it’s certainly one of the most anticipated. Therefore, it’s a no-brainer to enjoy our best Chargers vs. Bills picks for Week 3.

It’s also a no-brainer to make sure you check out how to make your Chargers vs. Bills predictions after claiming a GUARANTEED Novig promo code bonus - even in California!

🔥 Chargers vs. Bills Predictions for NFL Week 3, Sunday, 9/27

We mentioned the Bills’ TNF matchup, and in the first game in their new stadium, they put on a show in a 41-31 win over Jahmyr Gibbs and the Detroit Lions. That was after surging out to a 21-0 lead, so they were in control from the rip. Two huge wins to open the season are sure to have plenty of fans backing Buffalo with their Chargers vs. Bills predictions.

In that TNF matchup, we came through with the Detroit team total, and in Week 1, we had our NFL expert picks on David Montgomery scoring a TD against Buffalo. So, that means we should just take something with LA and call it a day, right? Perhaps, but when it comes to Chargers vs. Bills predictions, there are countless options.

Speaking of LA, we can’t forget how they started the season - with a rough loss to the Arizona Cardinals as huge home favorites. They followed that up with another rough showing at home against the Las Vegas Raiders, and that’s putting it lightly. After SIX fumbles (lost one, but still) and two picks, they had a holding call in the endzone, allowing a safety.

After all that, there is just no way that LA can be the focus of our Chargers vs. Bills predictions…right?

🏅 Chargers vs. Bills Expert Pick: LA Team Total Over 19.5 (57.5% at Novig)

Somehow, they still are, but no, we certainly aren’t going to call for an upset here. No matter how “due” you may feel a team is for a win, this is the juggernaut Bills. Perhaps getting away from LA is what Justin Herbert and company need, but regardless, we just have them putting up more points than we’ve seen thus far with our Chargers vs. Bills predictions.

We’ve already told you that we took this approach for Detroit in Buffalo’s last game, and it paid off despite them still losing by 10 and not covering the spread. That made it two straight games of the Bills defense allowing 31 points, and the first was to the Houston Texans. It’s worth noting that they scored just six points the following week!

In fact, they were held without a touchdown against the Cincinnati Bengals defense of all teams! That’s why we’re willing to make the top pick from our Chargers vs. Bills predictions on a market that most fans may find tough to back after LA’s 0-2 start. Also, if Buffalo is pouring it on as expected, that means the Chargers are putting their foot on the gas to keep pace.

That’s exactly what the Lions had to do after going down 21-0 early, and with how explosive Buffalo has looked, that means more and more possessions. However they get it done, the best bet from our top Chargers vs. Bills predictions for Week 3 is the LA team total over 19.5 (57.5% at Novig).

 

 

 

👀 How To Watch Chargers vs. Bills NFL Week 3

Outside of the primetime games, this is one of the games of the weekend, so don’t miss it and check out how to watch Chargers vs. Bills NFL Week 3:

  • Where: Highmark Stadium in Orchard Park, NY
  • When: 1 PM ET on 9/27
  • Watch on TV: FOX
  • Where to stream: YouTube TV, Fubo, Hulu + Live TV

🔢 Chargers vs. Bills Odds, Spreads, Total & Betting Lines

After back-to-back big wins, we aren’t surprised to see the latest Chargers vs. Bills odds for Week 3 clearly favoring Josh Allen and Buffalo:

 

 

 

🏉 Chargers vs. Bills Injury Report & Latest News

We have quite a few names on both sides of this matchup when it comes to Chargers vs. Bills injuries. With that in mind, we've shared the latest based on the Thursday practice report:

Los Angeles Chargers:

Buffalo Bills:

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