With just two Monday Night Football matchups remaining (Week 18 won’t have one), it’s time to make sure that we truly make the most of the ones that we have left. Next up sees the Indianapolis Colts hosting the San Francisco 49ers, and for the NFC vs. AFC clash, we’ve got our best 49ers vs. Colts predictions for MNF.

To fully ensure that we’re capitalizing on the remaining prime time games and our top 49ers vs. Colts picks, we’ll hook you up with a guaranteed Novig Sportsbook promo code bonus!

49ers vs. Colts Predictions for Monday Night Football, NFL Week 16

After nearly leading the Colts to the upset of the year over the Seattle Seahawks on Sunday, the team wasted no time announcing that Philip Rivers would once again be the starter for this matchup. The 44-year-old threw for 120 yards in the loss, but at least gets to play at home for Monday Night Football.

Although a factor for our 49ers vs. Colts predictions, we still see San Francisco as clear favorites. They’ve got a big storyline themselves, as they placed Brandon Aiyuk on the IR/left team list since they apparently haven’t seen them in a month or more. Clearly, his absence hasn’t been a big deal.

The 49ers still have a chance to earn the #1 seed in the NFC with some help, and Indy is still trying to keep their playoff hopes alive. A meaningful game for both teams means that you won’t want to miss our premium NFL best bets for Monday Night Football alongside our 49ers vs. Colts predictions to hit multiple NFL expert picks.
 

 

 

49ers vs. Colts Best Bet: San Francisco -6 Points (-115 at Novig)

We didn’t have to look far for a market that we found valuable since it’s a simple, standard market. We’ve seen the 49ers vs. Colts odds listing San Francisco as favorites from 5.5 and up to 6.5, and we’d be comfortable with anything less than a touchdown. Although they’re on the road, we’re confident that they can get the job done.

There is no weather to factor into our 49ers vs. Colts predictions like the Miami Dolphins playing in the cold in the most recent MNF game, since they’ll be indoors. More importantly, we don’t see Philip Rivers taking advantage of the 49ers where they can be exploited. San Francisco has the 25th-ranked defensive EPA per pass, but has been great against the run.

In other words, Indy simply doesn’t excel where San Francisco can be beaten. No Nick Bosa rushing the passer is their issue, but again, we don’t trust Indy’s passing attack enough. We may see an Alec Pierce explosive play or two, but not enough to have them pull off the upset. You could also consider a first-half spread as well.

In any case, we’re keeping things as basic as it gets by making the best bet from our 49ers vs. Colts predictions on San Francisco -6 points (-115 at Novig).
 

 

 

How To Watch NFL Week 16 Monday Night Football

For the penultimate MNF matchup, make sure that you don’t miss and check how to watch 49ers vs. Colts NFL Week 16 Monday Night Football here:

  • Where: Lucas Oil Stadium, Indianapolis, IN
  • When: 8:15 PM ET on 12/22
  • Watch on TV: ESPN, ABC
  • Where to stream: ESPN+
     
 

 

49ers vs. Colts Odds, Spreads, Total & Betting Lines

Halfway through the season, these 49ers vs. Colts odds for MNF would surprise you, but so much craziness has happened in Indy since then. Here are the latest lines at Novig Sportsbook:

 

 

49ers vs. Colts Injury Report & Latest News

We mentioned the unique Brandon Aiyuk situation in San Francisco, but what about other 49ers vs. Colts injury news? The aforementioned Nick Bosa has been out for a while, as has Fred Warner, so right now, we’ll be monitoring Ricky Pearsall and Tatum Bethune.

The big 49ers vs. Colts injury news in Indy is that of Sauce Gardner, and we also saw Bernhard Raimann go down in Sunday’s loss. With plenty of guys to keep tabs on, be sure to check in with the Fantasy Alarm NFL injury report.

 

 

 

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