MLB Home Run Picks Today: Best HR Predictions for April 21st, 2026
After some teams had Monday off and a strange slate that had an AM first pitch, it’s time to get into the full swing of the midweek series! What better way to do so than with some MLB home run picks? Admittedly, yesterday wasn’t the ideal slate for them, so let’s see what we find today; we’ll even piece things together into the best MLB home run parlay for today!
You’ll also want to check out the best fantasy sports promo codes from the top legal sites in your state. Make sure that you also crush your MLB DFS contests today with our DFS Playbook, Starting Lineups, Lineup Generator & DFS Tools!
⚾ Top MLB Home Run Picks for Today
Now that you’ve seen how to create and submit the best lineups, let’s take things a step further. Make sure that you also check out our MLB expert picks for today! Ok, we know that you want some dinger picks as well. We’ll break down each of our best MLB home run picks today, but so that you have the names ASAP, here you go:
- Bryce Harper: +440 at FanDuel Sportsbook
- Hunter Goodman: +350 at BetMGM Sportsbook
- Pete Alonso: +390 at Novig Sportsbook
🔥 Best Matchups for Home Runs Today, 4/21: Ballpark Factors & Weather Impact
Of course, each guy above has their own matchups and reasons for why they made the cut. However, there are still some factors that are always worth checking out for MLB home run picks, including our very own MLB weather report!
Others include pitching matchups, contact rate, and more. Let’s get into more specifics about our top MLB home run predictions for you.
Bryce Harper (+440)
Why not start at Wrigley Field? We love how wind alone can take balls over the fence, and the bats of the Philadelphia Phillies need to wake up. While they put up just one run last night, Bryce Harper is still leading off our MLB home run picks. We’re getting a better price than Kyle Schwarber here as well.
You could certainly go that route as well, but Harper is actually the better lefty hitter facing lefty pitchers. That’s what Philly will be getting today with the Chicago Cubs sending Shota Imanaga to the bump. We’re certainly not picking on him like he’s Patrick Corbin, but this is more about trusting the matchup-proof slugger.
It’s one of the more common names to target, but we’re still starting our best MLB home run picks for today with Bryce Harper to hit a HR (+440 at FanDuel).
Hunter Goodman (+350)
Yesterday, we gave out Will Smith of the Los Angeles Dodgers with a suggestion of taking Max Muncy for the safer route. Well, Muncy crushed two homers at Coors Field, and the Colorado Rockies remain at home to host the other SoCal team, which is why this game is part of our top MLB home run predictions today.
Colorado’s Micky Moniak has six dingers on the season, but Hunter Goodman is right behind him with five. They’re taking on Randy Vasquez, so if you want to go with the lefty Moniak, we couldn’t fault you. Even still, we’re sticking with the catcher - both he and Moniak were tied for the team lead with homers vs. San Diego last season as well.
With the classic thin-air conditions of Coors Field, we like Hunter Goodman to hit a HR (+350 at BetMGM) as part of our best MLB home run picks today.
Pete Alonso (+390)
If you checked out our overall best bets yesterday, you saw that we were on the over in the Orioles vs. Royals series opener. Admittedly, we needed all of it in the 9th or later, but a win’s a win. We’re going back to that series to add to our MLB home run picks by targeting Baltimore’s big offseason addition.
The Polar Bear needs to start living up to the expectations of fans in Charm City, as he’s got just two homers this season. He’ll be taking on Kris Bubic as the KC starter, but even if it doesn’t come in the first few innings, we won’t sweat too much. That’s because the Royals have the absolute worst bullpen ERA right now.
That was on perfect display last night, so let’s wrap up our best MLB home run picks today with Pete Alonso to hit a HR (+390 at Novig).
🚀 Longshot Home Run Picks Today
If somehow those odds weren’t juicy enough for you, not a problem. Let’s check out our best MLB home run longshot pick for today:
We mentioned Patrick Corbin, but we’re actually going to back one of his teammates. The wind is blowing out at Angel Stadium, Gimenez has three homers on the year, and is facing starter Jack Kochanowicz and a very subpar LA bullpen.
💲 Today’s Best MLB Home Run Parlay
Whether you want to just pick one of the above, one that includes your favorite team or otherwise, it’s entirely up to you. However, let’s provide you with the biggest approach of them all, which is with our best MLB home run parlay for today:
- Harper, Goodman & Alonso: +11011 at Novig, so $10 pays out $11,111
You’ve now seen several big numbers, so what’re you waiting for? Take full advantage of our best MLB home run picks for today and make a Tuesday feel like a Friday night!
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