MLB Home Run Picks Today: Best HR Predictions for April 15th, 2026
If there was ever a week to have the best MLB home run picks, it’s this one. These midweek series blasted off with NINE different players hitting multiple home runs, including some big names like Aaron Judge and Kyle Schwarber. Those are always two fan favorites when it comes to MLB home run predictions, and we’re here to share ours for today!
You’ll also want to check out the best fantasy sports promo codes from the top legal sites in your state. Make sure that you also crush your MLB DFS contests today with our DFS Playbook, Starting Lineups, Lineup Generator & DFS Tools!
⚾ Top MLB Home Run Picks for Today
Among the names noted above that came through for MLB home run picks, we also saw Mike Trout and Nolan Arenado do the same, and there were even THREE players that did so in the Diamondbacks vs. Orioles game alone! With that in mind, make sure that you’re also checking out our MLB expert picks.
While we’re going to break down each spot in more detail, if you just want the best MLB home run picks for today ASAP, here are the guys we have our eyes on:
- Gunnar Henderson: +425 at bet365 Sportsbook
- Oneil Cruz: +396 at DraftKings Sportsbook
- Bryce Harper: +359 at Novig Sportsbook
🔥 Best Matchups for Home Runs Today, 4/15: Ballpark Factors & Weather Impact
For fans out there who want more reasoning as to why we like these spots, we’ve got you covered there as well. From pitching matchups to ballpark factors and weather impact, here’s why these are our top MLB home run picks for today:
Gunnar Henderson (+425)
We need to get right into things with the Diamondbacks vs. Orioles series wrapping up nice and early today at 12:35 PM ET. The matchup being in Baltimore already helps out our MLB home run picks, as Camden Yards is a solid hitter’s ballpark, especially since moving in the left field fence.
We’ve also got some help on top of that, as the wind is blowing out at about 10 mph this afternoon! That’s ideal for Henderson, even though he’s facing a southpaw. We’re comfortable with this lefty vs. lefty crime, as the shortstop already has two homers against such pitchers this year in only 10 at-bats!
So, let’s start both the entire slate and our best MLB home run picks with Gunnar Henderson (+425 at bet365).
Oneil Cruz (+396)
We’re not going far from Baltimore with our next pick, and you’ll see that we aren’t even leaving Maryland or Pennsylvania for either of our best bets! This time, we’ve got an outfielder in our sights, who needs to bounce back from last night’s performance to cash our MLB home run picks. Thankfully, Cruz is facing Jake Irvin.
The Nats starter has already allowed three home runs across his first three starts this season en route to his 7.07 ERA. Even without the strong matchup, Cruz has already gone yard five times this season, and he already went 2-for-3 to start this series. We could cash one of our MLB home run picks on the first pitch of the game with Oneil Cruz (+396 at DraftKings).
Bryce Harper (+359)
We said that we aren’t leaving the area, as we’re heading to Philly next. Between Harper and Kyle Schwarber, they have two of the most popular guys for MLB home run picks, but we aren’t scared. There have been 20 and 14 runs in this Cubs vs. Phillies series thus far, so Citizens Bank Park is proving why it’s considered a hitter’s ballpark.
Like Camden Yards today, we’ve got the same double-digit winds blowing out for Harper to continue proving that he can crush lefties. He has just one home run against southpaws so far this season, but in his career, he’s got a .469 slugging percentage. So, let’s add Bryce Harper (+359 at Novig) to our top MLB home run picks!
🚀 Longshot Home Run Picks Today
When it comes to MLB home run predictions, you’re always going to be getting some great plus-money odds. However, there are still some that are far juicier than others. So, in addition to our best MLB home run picks above, how about a longshot?
- Ryan O’Hearn: +650 at DraftKings Sportsbook
We’re already on Cruz, so why not another Pirate? You’ve already seen the strong matchup against Irvin on the bump for Washington, and it goes beyond that. Even if they don’t go deep against him, the Nats also have the worst bullpen ERA so far this season after ending all of last year as the worst as well.
In addition to our MLB home run picks above, let’s go for a longshot play by adding Ryan O’Hearn (+650 at DraftKings) to the card.
💲 Today’s Best MLB Home Run Parlay
Now that you’ve got our top spots and even a longshot, let’s close things out with an epic potential payout. We’ve combined our top MLB home run picks below for the best MLB home run parlay for today:
- Henderson, Cruz & Harper: +9900 at Novig Sportsbook; $10 pays out $1,000
Whether you pair them all together for a massive payout or just pick your favorite, make the most of our best MLB home run picks and enjoy the slate!
Player News
{{item.text}}
{{analysis.analysis}}
