2025 MLB Spring Training Schedule, Games, Lineups & Betting Odds Today, 3/21

The 2025 MLB Spring Training action rolls on as teams continue their final preparations for Opening Day. With rosters taking shape and competition heating up, every inning counts for veterans looking to refine their form and prospects hoping to make a lasting impression. Managers are closely analyzing performances, while fans get a preview of what’s to come in the regular season.

Friday’s 2025 MLB Spring Training schedule is packed with intriguing matchups, featuring a mix of experienced stars and emerging talent. Below is the complete lineup for Friday, March 21, including game times, pitching duels, and TV coverage.

2025 MLB Spring Training Schedule Today, Friday, 3/21

• Houston Astros vs. St. Louis Cardinals – 1:05 PM ET
  • Valdez vs. Gray
• Minnesota Twins vs. Philadelphia Phillies – 1:05 PM ET (NBCSP+, MLBN)
  • Lopez vs. Wheeler
• Atlanta Braves vs. Tampa Bay Rays – 1:05 PM ET (FDSNSE, FDSNSUN)
  • Sale vs. Rasmussen
• Philadelphia Phillies vs. Toronto Blue Jays – 1:07 PM ET (Sportsnet)
  • Ross vs. Berrios
• St. Louis Cardinals vs. New York Mets – 1:10 PM ET (SNY)
  • McGreevy vs. Holmes
• Texas Rangers vs. Los Angeles Angels – 3:10 PM ET (FDSNW)
  • TBD vs. Hendricks
• Kansas City Royals vs. Oakland Athletics – 4:05 PM ET
  • Ragans vs. Severino
• San Diego Padres vs. Chicago Cubs – 4:05 PM ET
  • TBD vs. TBD
• Seattle Mariners vs. Kansas City Royals – 4:05 PM ET
  • Evans vs. Lorenzen
• Cleveland Guardians vs. San Francisco Giants – 4:05 PM ET
  • Lively vs. Webb
• Chicago White Sox vs. Cincinnati Reds – 4:05 PM ET
  • Burke vs. Singer
• Los Angeles Angels vs. Colorado Rockies – 4:10 PM ET
  • Kikuchi vs. TBD
• Cincinnati Reds vs. Seattle Mariners – 4:10 PM ET
  • Greene vs. Gilbert
• Detroit Tigers vs. Baltimore Orioles – 6:05 PM ET
  • Skubal vs. Suarez
• Pittsburgh Pirates vs. Boston Red Sox – 6:05 PM ET (SNP+, NESN)
  • Keller vs. Crochet
• Miami Marlins vs. Washington Nationals – 6:05 PM ET
  • Quantrill vs. TBD
• New York Yankees vs. Detroit Tigers – 6:05 PM ET (Gotham, FDSNDTX, MLBN)
  • Rodon vs. Montero
• Arizona Diamondbacks vs. Milwaukee Brewers – 9:10 PM ET (FDSNWI, MLBN)
  • Burnes vs. Peralta

2025 MLB Spring Training Games To Watch & Betting Odds Today, 3/21

• Astros (NA) vs. Cardinals (NA)
• Twins (NA) vs. Phillies (NA)
• Braves (-108) vs. Rays (-112)
• Phillies (NA) vs. Blue Jays (NA)
• Cardinals (NA) vs. Mets (NA)
• Rangers (NA) vs. Angels (NA)
• Royals (NA) vs. Athletics (NA)
• Padres (+110) vs. Cubs (-130)
• Mariners (NA) vs. Royals (NA)
• Guardians (+145) vs. Giants (-175)
• White Sox (NA) vs. Reds (NA)
• Angels (NA) vs. Rockies (NA)
• Reds (NA) vs. Mariners (NA)
• Tigers (NA) vs. Orioles (NA)
• Pirates (+145) vs. Red Sox (-175)
• Marlins (+130) vs. Nationals (-155)
• Yankees (NA) vs. Tigers (NA)
• Diamondbacks (-105) vs. Brewers (-115)

Odds are subject to change. Visit DraftKings Sportsbook for live updates before placing bets.

How To Watch 2025 MLB Spring Training Today

Catch today’s action on the following networks:

• NBCSP+, MLBN, FDSNSE, FDSNSUN, Sportsnet, SNY, FDSNW, SNP+, NESN, Gotham, FDSNDTX, FDSNWI

For games without a listed broadcast, check team websites or MLB streaming services.

MLB Spring Training Lineups Today, 3/21

Spring Training lineups fluctuate as teams test different combinations and assess depth. Expect extended playing time for those competing for final roster spots. 

Stay tuned for our latest confirmed MLB Lineups with batting orders, pitching updates, and any last-minute adjustments.

How To Bet On MLB Spring Training Today At DraftKings Sportsbook & Claim Your $200 Bonus

New users can take advantage of DraftKings Sportsbook’s special promo—no code required. Sign up here, place a $5 bet on any Spring Training game, and receive $200 in bonus bets win or lose!

Spring Training may not impact the standings, but its influence on roster battles and player development is undeniable. With plenty of games still to come, now is a great time to dive into the baseball betting scene.