This Saturday night, all eyes will be on Beaver Stadium as the No. 6 Oregon Ducks make their way across the country to take on the No. 3 Penn State Nittany Lions.

This highly anticipated top-10 clash carries significant implications for both the Big Ten and the College Football Playoff, with both teams entering the game undefeated at 4-0. On paper, Penn State enjoys the advantage of playing at home – and the added excitement of competing under the lights in one of the sport's most challenging atmospheres.

However, there are lingering doubts about how much adversity James Franklin’s team has truly faced. On the other hand, Oregon has already secured solid victories against decent opponents, proving they’re serious contenders for the championship. So, which side of the spread presents the best value when making #6 Oregon vs. #3 Penn St. picks?

#6 Oregon vs. #3 Penn St. Predictions for College Football Week 5, Saturday, 9/27

If this game were taking place on a neutral field, Oregon would probably be the favorite. Dan Lanning’s Ducks have demonstrated a sharper performance over the past four weeks, dominating both offense and defense while revealing few vulnerabilities.

However, in Happy Valley at night, when scouring selections for #6 Oregon vs. #3 Penn St. predictions, you’ll see that Penn State holds a slight advantage in the betting odds. The Nittany Lions are currently favored by -3.5, indicating that oddsmakers view Beaver Stadium as a significant factor.

The question remains: Is that difference too substantial?

 

 

 

#6 Oregon vs. #3 Penn St. Spread Pick: Ducks +3.5 (-110 at Rebet)

In contrast to Penn State, Oregon has already faced and triumphed over legitimate opponents. The Ducks kicked off the season with a decisive victory against Oklahoma State, followed it up with a rivalry win over Oregon State, and easily defeated Northwestern. While none of these teams are playoff contenders, they are certainly more formidable than Penn State’s initial schedule, which included teams like Villanova and FIU.

More crucially, Oregon has executed nearly flawlessly. The offensive line has allowed only one sack in four games, and quarterback Dante Moore – a former five-star recruit who’s now emerging as a star – has performed as expected. He’s effectively distributing the ball among a talented receiving group, minimizing turnovers, and displaying the composure desired from a quarterback heading into a White Out game.

On the defensive side, the Ducks have yet to allow a touchdown pass. Their secondary has excelled at forcing incompletions and preventing big plays. This will place pressure on Drew Allar to perform efficiently and without mistakes, a challenge he has not consistently met even against weaker teams.

Nevertheless, the environment cannot be overlooked. Penn State at night creates one of the most fearsome atmospheres in college football. On the field, Penn State showcases one of the top running back duos in the nation with Nick Singleton and Kaytron Allen. Supporting them is an offensive line that ranks among the finest in the Big Ten.

On the defensive side, new coordinator Jim Knowles has ramped up the Havoc. Penn State is ranked in the top five nationally for havoc rate and adjusted EPA allowed, consistently disrupting plays behind the line of scrimmage.

Penn State could very well emerge victorious in this matchup. The advantage of playing at home is significant, and their defense has the capability to unsettle a young quarterback. However, the spread allows for Oregon to stay competitive – and therein lies the value.

This marks the first “true” opponent Penn State has faced all season, and while they’ve performed well against lesser competition, nothing can replace the experience of live reps against top-tier talent. Oregon has, to a certain extent, already faced those challenges, and it reflects in their execution.

If the Ducks' offensive line can protect Moore, their balanced offensive strategy should produce enough scoring to keep pace with Penn State. At the same time, the Ducks’ secondary is competent enough to limit explosive plays from Allar and company. Opting for the Ducks +3.5 is the play for our #6 Oregon vs. #3 Penn St. predictions in what shapes up to be a thrilling contest that comes down to the wire.

 

 

 

How To Watch #6 Oregon vs. #3 Penn St. College Football Week 5

  • Date: Saturday, September 27, 2025
  • Time: 7:30 PM ET
  • Channel: NBC
  • Location: Beaver Stadium, University Park, PA

#6 Oregon vs. #3 Penn St. Odds, Spreads, Total & Betting Lines

Considering our #6 Oregon vs. #3 Penn St. predictions, we’re sharing the latest #6 Oregon vs. #3 Penn St. odds from Rebet for this exciting matchup:

  • Money Line (ML): Ducks +145 | Nittany Lions -175
  • Spread: Ducks +3.5 (-110) | Nittany Lions -3.5 (-110)
  • Over/Under (O/U): 52.5 (O: -110 | U: -110)

 

 

 

#6 Oregon vs. #3 Penn St. Injury Report & Latest News

Oregon Injury Report

  • J. Ressler (WR) – Questionable, Undisclosed
  • D. Gresham (WR) – Questionable, Undisclosed
  • B. Boulton (OG) – Questionable, Undisclosed
  • D. Brew (CB) – Questionable, Undisclosed
  • B. Platt (LB) – Questionable, Undisclosed
  • E. Stewart (WR) – Out, Knee
  • T. McNutt (CB) – Out, Leg

Penn State Injury Report

  • L. Samuel (WR) – Questionable, Undisclosed
  • A. Olesh (TE) – Questionable, Undisclosed
  • M. Outten (WR) – Questionable, Undisclosed
  • B. Kritza (QB) – Questionable, Undisclosed
  • R. Adirika (DL) – Questionable, Undisclosed
  • L. Horan (OG) – Questionable, Undisclosed
  • M. Granville (DL) – Questionable, Undisclosed
  • L. Cunningham (WR) – Questionable, Undisclosed
  • D. Cook (DL) – Questionable, Undisclosed
  • P. Gonzalez (WR) – Questionable, Undisclosed
  • K. Jackson (LB) – Questionable, Undisclosed
  • B. O'Hara (OG) – Questionable, Undisclosed
  • M. Williams (DL) – Questionable, Undisclosed
  • J. Brown (WR) – Questionable, Undisclosed
  • D. Nastasi (CB) – Questionable, Undisclosed
  • M. Robinson (DL) – Questionable, Undisclosed
  • J. Mayer (DL) – Questionable, Undisclosed
  • A. Davis (RB) – Questionable, Undisclosed
  • K. Artis (DL) – Questionable, Undisclosed
  • K. Saunders (WR) – Questionable, Undisclosed

 

 

 

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