The 2026 college football season rolls on! Saturday’s matchup between the Ohio State Buckeyes and Indiana Hoosiers headlines CFB Week 7. That means it’s time to dive into #4 Ohio State vs. #5 Indiana predictions before kickoff. We’ll preview the game, break down the matchup, and dish out expert #4 Ohio State vs. #5 Indiana picks. Plus, get to know the latest #4 Ohio State vs. #5 Indiana odds ahead of Saturday’s showdown.
#4 Ohio State vs. #5 Indiana Predictions for CFB Week 7, Saturday 10/17
Before we get to our #4 Ohio State vs. #5 Indiana predictions, let’s set the stage for Saturday’s game. The Buckeyes enter as 3.5-point road favorites with a 50.5 over/under on BetMGM Sportsbook. The Hoosiers are 6-0 ahead of this matchup, while Ohio State is 5-1. Both are 3-0 in Big Ten play thus far.
Without further ado, let’s dive into our #4 Ohio State vs. #5 Indiana picks. There’s a certain betting angle worth locking in before Saturday’s matchup kicks off. Good luck!
#4 Ohio State vs. #5 Indiana Expert Pick: Under 50.5 Total Points (-110 on BetMGM Sportsbook)
Ohio State and Indiana both have elite-level defenses. Expect a lower-scoring, defensive matchup to keep the explosive offenses in check. Let’s lock in the under 50.5 total points for our #4 Ohio State vs. #5 Indiana predictions.
The Buckeyes allow only 13.2 points and 246.8 total yards per game, both ranking top 10 in the country. They also rank 7th nationally in defensive EPA/Play and 4th in defensive success rate. It’s a dominant unit that will be ready to slow down Indiana’s potent offense.
Meanwhile, Indiana allows just 11.8 PPG (5th in FBS) and 263.5 total yards per contest (11th). The Hoosiers also rank 15th in defensive success rate. The defense was among the best in the country last year, and it’s the case again this season.
This projects as a defensive grinder with points being tough to come by on both sides. When Ohio State and Indiana met in the Big Ten title game last season, it was a 13-10 final that saw just 5 combined scoring drives. Both offenses moved the ball but struggled to finish in the red zone.
Stopping Ohio State will be Indiana’s toughest test so far, especially with Jeremiah Smith lurking. However, the Hoosiers successfully did it in last year’s matchup. Interestingly, the defense focused on shutting down the Buckeyes’ supporting cast while allowing Smith to go for 144 yards on eight catches. IU will likely take a similar approach, forcing anyone else to beat it.
Plus, Ohio State’s offense has been slowed in its toughest matchups over the past two seasons. The Buckeyes scored 14 points or fewer against Texas, Indiana, and Miami (FL) last year. They were also somewhat limited on the road against Michigan (27 points) and Washington (24). This year, Iowa and Texas both held OSU under their season averages.
Meanwhile, Indiana’s offense hasn’t truly proven itself in its hardest games. The Hoosiers scored 20 and 29 points against Nebraska and Northwestern, respectively. Ohio State presents a much tougher challenge, and we could see IU’s offensive inefficiencies come to focus.
How To Watch #4 Ohio State vs. #5 Indiana CFB Week 7
- Date: Saturday, October 17, 2026
- Time: 12:00 PM ET
- Location: Memorial Stadium, Bloomington, Indiana
- TV: FOX
#4 Ohio State vs. #5 Indiana Odds, Spread, Total & Betting Lines
After #4 Ohio State vs. #5 Indiana predictions, let’s take a look at the betting lines for this college football matchup. Here are the latest #4 Ohio State vs. #5 Indiana odds from BetMGM Sportsbook ahead of Saturday’s showdown.
- Spread: Ohio State -3.5 (-105) | Indiana +3.5 (-112)
- Moneyline: Ohio State -175 | Indiana +145
- Over/Under: 50.5 (Over -110 | Under -110)
#4 Ohio State vs. #5 Indiana Injury Report & Latest News
Ohio State Buckeyes:
- DB Leroy Roker III – Out
- RB Ja’Kobi Jackson – Out
- WR Amari Valerio-Hudson – Out
- DB Khmari Bing – Out
- OL Jaxon Powell – Out
- OL Austin Siereveld – Out
- WR Brock Boyd – Questionable
- RB Anthony Rogers – Questionable
- RB Isaiah West – Questionable
- DE Khary Wilder – Questionable
- OL Deontae Armstrong – Questionable
Indiana Hoosiers:
- RB Khobie Martin – Doubtful
- TE Andrew Barker – Questionable
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