As the NFL's Week 3 slate kicks off on Sunday, September 21, with a marquee matchup headlining the afternoon action, bettors are zeroing in on player prop opportunities that promise high value amid early-season surprises and injury ripples. 

This week's card is ripe with exploitable edges—think over/under rushes, receiving yards, and anytime TDs for standout performers across the league. 

Whether you're chasing long-shot payouts or steady EV plays, our curated best player prop picks below dissect the stats, matchups, and trends to help you build a winning card before kickoff.

 

Best NFL Week 3 Player Prop Picks - Brock Bowers Over 60.5 Yards Receiving

Brock Bowers delivered a massive performance in Week 1 versus the Patriots, but a nagging knee injury had him listed as questionable for Week 2. He played through it, though he appeared noticeably limited and lacked his typical burst.

With another full week of healing under his belt, Bowers heads into this Raiders-Commanders matchup without any injury tag, indicating he's put that knee issue firmly in the rearview.

The Commanders' defense was just torched by Tucker Kraft, who piled up 124 yards and a score on only six receptions, highlighting Washington's ongoing struggles against tight ends—= a weakness that lingered from last year.

Assuming Bowers is back to full speed, it wouldn't shock me if he pushes for 100+ yards as the Raiders' undisputed top receiving option which makes his line of 60.5 yards awfully low.

 

NFL Week 3 Player Props: Ja'Marr Chase Over 69.5 Yards Receiving

I get that Joe Burrow is sidelined this week, but let's not overlook Ja'Marr Chase's monster finish last week: 165 yards on 14 catches. Burrow managed just seven completions for 76 yards total, with only 37 of those going to Chase meaning Chase racked up a whopping 128 yards from passes thrown by Jake Browning alone.

As one of the NFL's premier playmakers, Chase has that rare ability to turn a simple 5-yard toss into an explosive 60-yard romp without needing much room to operate.

I'm riding with Chase's elite talent here to smash well past his 69.5-yard receiving total for this weekend.

 

NFL Week 3 Prop Bets: Rome Odunze Over 63.5 Yards Receiving

It's baffling that this line remains so modest. Odunze has emerged as the Bears' leading receiver across the opening two weeks, and now they've got a favorable home tilt against a vulnerable Dallas Cowboys defense that's missing DaRon Bland yet again.

Add in a sky-high 50.5 over/under for the game, with Chicago slotted as the home underdog, and all signs point to a potential barnburner.

Given the buzz around a high-scoring affair and Caleb Williams peppering Odunze with 20 targets through those initial games, this prop screams value from every angle.

 

NFL Week 3 Football Player Props: Josh Jacobs Under 77.5 Rushing Yards

Alright, I get that this pick might raise some eyebrows, but the Cleveland Browns have straight-up stonewalled Chase Brown and Derrick Henry, limiting them to a measly 2.0 and 2.1 yards per carry, respectively.

Just last week, Henry trudged through 11 carries for only 23 yards, and back in Week 1, Brown managed 21 totes for a paltry 43 yards.

Sure, the Browns as a whole might not be lighting up the league, but that front seven is putting in elite-level effort.

Jacobs has held his own over the first two weeks, yet he's scraping by with just 3.6 yards per carry on average.

My sole concern here is the sheer volume of Green Bay's hitting the road as favorites, so Jacobs might rack up 18-20 attempts, and one explosive burst could blow up the line. That said, I'm doubling down on this Browns D after their dominant showing last week.

 

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