When the NFL season begins with a thrilling Week 1 on Sunday, September 7, 2025, player prop bets provide a thrilling means to get immersed in the action. From quarterbacks throwing deep to running backs churning out extra yardage, such bets allow you to home in on individual production capable of winning or losing a game. 

Our handpicked list of the best player prop predictions identifies key opportunities through matchups, trends, and statistics and allows you to make savvy decisions for a memorable opening weekend. Prepare to take your NFL experience to the next level with these key picks!

Best NFL Week 1 Player Prop Picks - Bo Nix Under 31.5 Pass Attempts

The game doesn't project as a high-scoring battle, with the Broncos favored by 8.5 points at home against the Tennessee Titans, featuring the week's second-lowest total at 42.5 points.

Denver could jump ahead early and lean on their rushing attack to secure the win in the second half.

I’m bullish on Bo Nix’s outlook this season and expect a strong performance, with a stat line around 20-of-28 passing quite plausible.

 

NFL Week 1 Player Props: Maxx Crosby Over 0.5 Sacks

As a Patriots fan, I acknowledge the offensive line's slight improvement but remain skeptical about its performance, especially with first-round pick Will Campbell playing through an ankle injury against one of the NFL's top pass rushes. 

Rainy weather in Foxboro will likely persist throughout the game, potentially limiting pass-rush opportunities if the Patriots focus on running the ball. Still, I predict Crosby will record at least one sack.

 

NFL Week 1 Prop Bets: Tyreek Hill Over 70.5 Receiving Yards

The fantasy community seems to be sleeping on Tyreek Hill's elite talent, overlooking his 2024 season hampered by subpar QB play and injuries.

Heading into Week 1, reports confirm he's fully healthy, and any tension with Tua Tagovailoa appears resolved.

On-field chemistry is what counts, and Tua should deliver the ball to Hill when he’s open. Still one of the NFL’s fastest players, Hill is just a year removed from consecutive 1,700-yard seasons.

At a discounted yardage prop of over 70.5 yards, he’s a prime bet to exceed expectations, potentially with a single explosive play.

 

NFL Week 1 Football Player Props: Geno Smith Under 32.5 Pass Attempts

As we head into Week 1 of the 2025 NFL season, the Seattle Seahawks face off against the New England Patriots in Foxborough, a matchup that sets up perfectly for a grind-it-out, weather-impacted affair. 

Geno Smith's pass attempt prop is sitting at 32.5, and I'm leaning heavily toward the under here. Smith's career has seen him fluctuate between high-volume games and more conservative scripts, but the contextual factors in this spot weather, personnel changes, and game flow point to a run-first approach that keeps his attempts suppressed

 

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