Looking for the best NFL player prop picks today for Week 5's Sunday slate? From the league's worst pass defense to a Patriots secondary missing four cornerbacks, there is no shortage of injury-driven opportunity on the board. Below, we break down our top NFL Sunday Week 5 player prop picks, complete with the lines and the matchup context behind each play.

 

 

 

Best NFL Sunday Week 5 Player Prop Picks

Detroit's defense is allowing a league-high 304 passing yards per game, New England is down four cornerbacks, Seattle's backfield has been reduced to Emanuel Wilson and a banged-up supporting cast, and Denver's offense gets a new voice with Sean Payton calling the plays. Here are the props we like best from that slate.

Lions vs. Cardinals Player Props: Jacoby Brissett Over 274.5 Passing Yards

Brissett's profile is volume over efficiency, throwing 38 times per game with a league-low 5.4 yards per attempt, and this matchup should push the volume even higher. Detroit has the NFL's worst pass defense at 304 passing yards allowed per game, 23.7 more than the next-worst unit, along with the league's highest total yardage allowed and the 31st-ranked scoring defense at 31.8 points per game. Brissett has already thrown for 277 yards against the Chargers and 280 against the 49ers, the latter on 52 attempts, and with Detroit favored by 5.5 and fully capable of putting up points, Arizona figures to be throwing from behind again. He coughed up three interceptions in last week's loss to the Giants, but he gets about as friendly a matchup as a quarterback can ask for, and clearing 274.5 passing yards looks very attainable.

Broncos vs. Chargers Player Prop Bets: J.K. Dobbins Over 13.5 Rushing Attempts

Dobbins has led the Broncos in carries in every game this season, totaling 46 attempts for 161 yards, with double-digit carries in each of the last three, and the Denver offense now gets a significant change with Sean Payton taking back play-calling duties from offensive coordinator Davis Webb. Payton called the plays from 2023 through 2025, including last year's 14-3 season in which Dobbins averaged 15.3 carries per game over 10 games before a foot injury. Rookie Jonah Coleman remains on injured reserve, leaving Dobbins and RJ Harvey, who has been used mostly as a receiver, to share the backfield, with Dobbins taking the early-down work. Denver is a 3.5-point road favorite against a winless Chargers team, a script that favors the ground game. He has topped this number just once, with 17 carries against the Rams, but a new play-caller and a favorable game script point toward a bigger workload, and 13.5 carries looks like a good number to target.

49ers vs. Seahawks Player Props: Emanuel Wilson Over 59.5 Rushing Yards

Wilson has stepped into the lead role in Seattle's backfield with Jadarian Price on injured reserve until at least Week 8, and Zach Charbonnet ruled out again as he works back from a torn ACL, and he has run with it, rushing for 92 yards on 21 carries against Arizona in Week 2 and 81 yards and a touchdown on 21 carries against the Chargers last week. In that Chargers game he played 60% of the snaps and took 21 of Seattle's 28 running back carries and four of its five running back targets, turning 25 touches into 120 yards and two touchdowns. San Francisco will be without Nick Bosa for a third straight game, along with defensive tackle James Thompson Jr. and safety Marques Sigle, and Mykel Williams is only now returning from an ACL tear. With the Seahawks slight home favorites, Wilson looks like a strong bet to clear 59.5 rushing yards on another heavy workload.

Raiders vs. Patriots Player Prop Bets: Kirk Cousins Over 224.5 Passing Yards

Cousins leads the NFL with 11 touchdown passes and is averaging 256.5 passing yards per game, including 365 yards on 52 attempts in last week's 30-27 loss to Kansas City, and this week he draws a Patriots secondary that has been gutted. New England has ruled out starting cornerbacks Christian Gonzalez and Carlton Davis III, along with backups Karon Prunty and Channing Canada, leaving it with only four healthy cornerbacks. Las Vegas is missing receiver Jalen Nailor, but Brock Bowers gives Cousins a reliable target, and the Raiders are 3.5-point road underdogs who figure to be throwing plenty. New England allowed only 170 passing yards per game through three weeks, but that was before the injuries piled up, and with showers possible and light wind in the forecast, the conditions look manageable. Clearing 224.5 passing yards looks like a comfortable number for a quarterback averaging 256.5.

How to Bet on NFL Week 5 Sunday Player Props at Novig Sportsbook & Claim Your Spend $10, Get $25 Bonus with Promo Code ALARM

New users can back any of these Week 5 Sunday player prop picks at Novig Sportsbook and unlock a Spend $10, Get $25 Bonus offer using promo code ALARM. Sign up, make a qualifying $10 deposit and wager, and the bonus lands in the account automatically, with no waiting on rollover requirements before getting started. It's a straightforward way to add extra plays around a full Sunday slate already loaded with value.