Week 10 NFL action on Sunday, November 9, brings plenty of value on PrizePicks, especially in the receiving and rushing categories. We're targeting Demario Douglas of the New England Patriots and James Cook of the Buffalo Bills, both in spots primed for production. These picks leverage increased workloads, favorable matchups, and game scripts that tilt toward their strengths. Dive into the reasoning below for your PrizePicks lineup.

 

 

 

PrizePicks NFL DFS Picks for NFL Week 10, 11/9: NFL DFS Projections

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Demario Douglas PrizePicks NFL Week 10 Pick: More than 3.5 Receptions

Douglas is set for a boosted role with Kayshon Boutte expected to be inactive for the Patriots' matchup against the Tampa Bay Buccaneers. Last week against the Atlanta Falcons, Douglas posted a season-high four receptions on six targets, showcasing his growing involvement in the offense.The Bucs' secondary is particularly generous to slot wide receivers, ranking seventh in receptions allowed to the position. With Rhamondre Stevenson also sidelined, New England figures to lean heavily on the pass as underdogs in this game. That should translate to more targets for Douglas, who operates primarily from the slot. In a pass-heavy script, hitting over 3.5 receptions is well within reach.
 

 

 

James Cook PrizePicks NFL Week 10 Pick: More than 86.5 Rushing Yards

Cook's recent dominance makes him a must-consider for PrizePicks in Week 10 against the Miami Dolphins. Miami's run defense is among the league's worst, sitting in the bottom four and allowing 145.6 rushing yards per game. Lead backs have topped 90 yards against them in five of nine contests this year.Fresh off the injury report, Cook delivered a historic performance last week, rushing for 100 yards against the Kansas City Chiefs, the first RB to do so since 2023. He followed up a 200-plus yard explosion against Carolina the week before. With the Bills in a favorable spot to pound the rock.
 

 

 

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