As the old saying goes, “Good teams win, great teams cover.” We are back for week two with our picks against the spread! Week One was one of the more thrilling starts to the season in recent memory, and I am fired up for Week Two!

Below, we will be breaking down our NFL Week Two Picks Against The Spread while also going through the NFL Week 2 schedule. So without further ado, let's dive in!

 

 

 

NFL Week Two Picks Against The Spread + NFL Week 2 Schedule Predictions

For the NFL Week Two Schedule, we have all 32 teams playing in 16 games, including a Monday Night Football doubleheader. In the following section, you will find my predictions, with my NFL Week Two Picks Against The Spread highlighted in bold. All lines are courtesy of DraftKings Sportsbook:

 

 

 

NFL Week 1 Picks Against The Spread: Los Angeles Rams -5.5 (-110 at Caesars Sportsbook)

The Los Angeles Rams' season opener was a low-scoring brawl against the Houston Texans, a team that bolsters one of the most talented defenses in the league with stars at every level. Despite losing their top target, Puka Nacua, for a portion of the game to be evaluated for a concussion, along with needing to be bandaged up a bit, the Rams were able to come away with a 14-9 victory.

On the other side, the Tennessee Titans faced off against another top defense, the Denver Broncos, in rookie Cam Ward's NFL debut. While they may have been defeated 20-12, their defense was able to force four turnovers, and Cam Ward showed off his play extension ability on several occasions despite very little help on offense. I believe Ward's future is bright in the NFL, but this one is simple for me; the Titans have failed to cover in 10 of their last 12 home games, the Rams played against a much tougher defense than the Titans and still won by five, Sean McVay will outcoach Brian Callahan, and I do not see Stafford making as many mistakes as Bo Nix and the Broncos made on Sunday. With the expectation that Nacua won't miss half of the game again, I think the Rams should comfortably win this one. 

 

 

 

NFL Week 1 Picks Against The Spread: Tampa Bay Buccaneers +2.5 (-102 at FanDuel Sportsbook)

We already discussed the slugfest that was the Rams vs. Texans game, but the Buccaneers were in a tough one as well against the Atlanta Falcons, snatching a victory from the jaws of defeat, 23-20. Baker Mayfield did not have his most efficient day, finishing with a completion percentage of just over 50%, but when it came down to it and the Bucs needed a play, he delivered. 

Meanwhile, the Texans' offense looks lost, with a weak offensive line and fewer weapons on the outside. The run game was more effective than I was expecting, with Nick Chubb leading the way, but I don't think it will work as well with Vita Vea clogging the line of scrimmage. 

Realistically, I think this could be another close, low-scoring game, but I trust Baker Mayfield and the Bucs offense more in these moments than C.J. Stroud and his supporting cast. I think it is incredibly unlikely that the Texans would be able to beat the Buccaneers by more than one score, barring any major injuries, let alone beat them at all. So, I love the value of getting the Bucs as +2.5 underdogs.

 

 

 

How to Bet on NFL Week 1 Picks Against The Spread with Today's DraftKings Promo

Looking to tail our NFL Week Two Picks Against The Spread? Well, look no further than DraftKings Sportsbook, where you can take advantage of today’s DraftKings promo for the NFL, where you’ll be unlocking a two-part welcome bonus valued at $500 that is completely guaranteed! 

Just sign up now to DraftKings Sportsbook, place a bet $5 or more on one of our picks against the spread (or anything else that you would like), and successful or not, you’ll receive $300 worth of bonus bets and $200 off NFL Sunday Ticket! You don’t even have to worry about it winning!

 

 

 

NFL Week 1 Schedule

To make sure you get your NFL Week 2 Picks in before kickoff, we have listed when each game will be played for your convenience:

Thursday Night Football (September 11th, 8:15 PM ET):

  • Commanders vs. Packers

Sunday, September 14th, 1:00 PM ET:

  • Giants vs. Cowboys
  • Seahawks vs. Steelers
  • Rams vs. Titans
  • Bills vs. Jets
  • Patriots vs. Dolphins
  • Jaguars vs. Bengals
  • 49ers vs. Saints
  • Browns vs. Ravens
  • Bears vs. Lions

Sunday, September 14th, 4:05 PM ET:

  • Broncos vs. Colts
  • Panthers vs. Cardinals

Sunday, September 14th, 4:25 PM ET:

  • Eagles vs. Chiefs

Sunday Night Football (September 14th, 8:20 PM ET):

  • Buccaneers vs. Texans

Monday Night Football (September 15th, 7:00 PM ET):

  • Buccaneers vs. Texans

Monday Night Football (September 15th, 10:00 PM ET):

  • Chargers vs. Raiders

Be sure to come back and check out our NFL Week Two Picks Straight Up, or take advantage of our DraftKings promo by signing up now!