As the old saying goes, “Good teams win, great teams cover.” We are back for Week 5 with our picks against the spread! Week 4 provided us with a lot of shakeup, and with byes starting up this week, we need to be smart with our picks!

Below, we will be breaking down our NFL Week 5 Picks Against The Spread while also going through the NFL Week 5 schedule. So without further ado, let's dive in!

 

 

 

NFL Week Two Picks Against The Spread + NFL Week 5 Schedule Predictions

For the NFL Week 5 Schedule, we have all 28 of the 32 teams playing in 14 games, including an international game. This is our first week of byes, with the Atlanta Falcons, Chicago Bears, Green Bay Packers, and Pittsburgh Steelers having the week off. In the following section, you will find my predictions, with my NFL Week 4 Picks Against The Spread highlighted in bold. All lines are courtesy of DraftKings Sportsbook:

 

 

 

NFL Week 5 Picks Against The Spread: Tennessee Titans +7.5 (-110 at BetMGM Sportsbook)

This was a tough pick to make, but I don't see the Titans losing this game by more than one touchdown. The Arizona Cardinals are entering this game without their top two running backs, with James Conner being out for the season and Trey Benson just being placed on IR, so the Cardinals will be relying on a run game led by Emari Demercado and Michael Carter. I wouldn't say that is the most ideal situation, especially when they will be running up against what I view as one of the most underrated defensive tackle duos in the league: Jeffery Simmons and T'Vondre Sweat. If they are able to slow down the run, the Cardinals will have to rely on the arm of Kyler Murray and the passing game, which has been inconsistent at best.

While I like the Cardinals' defense, the Titans will be adding a much-needed reinforcement in the run game with Tyjae Spears returning from IR. With Cam Ward continuing to grow in the offense around him, plus more reliability in the run game, I think this game will certainly come down to one score, and it could even end up being a trap game for this banged-up Cardinals team.

 

 

 

NFL Week 5 Picks Against The Spread: Minnesota Vikings -4.5 (-105 at DraftKings Sportsbook)

Who would've thought that NFL Week 5 would bring us a matchup between Carson Wentz and Dillon Gabriel? This was NOT on my bingo card, but here we are. These international games are always a little wacky, but I do need to give the Vikings a bit of a leg up because this is their second week in a row where they are playing overseas. They are more acclimated to it at this point than the 1-3 Cleveland Browns.

In this game, the Browns are trotting out a third-round rookie quarterback in his first NFL start against a defensive coordinator in Brian Flores who is 5-0 against rookie QBs with the Minnesota Vikings and 9-1 overall. Not exactly the most ideal first start in your career, especially with the added wrinkle of the game being in London. 

I would say that at least the Browns defense should be able to make some noise with the Vikings' offensive line being banged up, but superstar pass rusher Myles Garrett did not practice yesterday with an ankle injury, so that is another thing to keep an eye on here. With two offenses that bring a lot of questions into this game, paired up with incredibly talented defenses, give me the offense sporting the veteran QB, the more trustworthy coach, who has already been dealing with the jetlag for an extra week. 

 

 

 

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NFL Week 5 Schedule

To make sure you get your NFL Week 5 Picks in before kickoff, we have listed when each game will be played for your convenience:

Thursday Night Football (October 2nd, 8:15 PM ET):

  • 49ers vs. Rams

London Game (October 5th, 9:30 AM ET):

  • Vikings vs. Browns

Sunday, October 5th, 1:00 PM ET:

  • Cowboys vs. Jets
  • Giants vs. Saints
  • Raiders vs. Colts
  • Dolphins vs. Panthers
  • Broncos vs. Eagles
  • Texans vs. Ravens

Sunday, October 5th, 4:05 PM ET:

  • Titans vs. Cardinals
  • Buccaneers vs. Seahawks

Sunday, October 5th, 4:25 PM ET:

  • Lions vs. Bengals
  • Commanders vs. Chargers

Sunday Night Football (October 5th, 8:20 PM ET):

  • Patriots vs. Bills

Monday Night Football (October 6th, 8:15 PM ET):

  • Chiefs vs. Jaguars

Be sure to come back and check out our NFL Week 5 Picks Straight Up, or take advantage of our DraftKings promo by signing up now!