As the old saying goes, “Good teams win, great teams cover.” We are back for Week 10 with our picks against the spread! Last week, I asked for a more exciting slate, and wow. Week 9 certainly delivered. Now that we have passed both the midpoint of the NFL season and the trade deadline, we are bound to have some more wild weeks like that one, so fingers crossed for another game like Bears vs. Bengals!

Below, we will be breaking down our NFL Week 10 Picks Against The Spread while also going through the NFL Week 10 schedule. So without further ado, let's dive in!

 

 

 

NFL Week 10 Picks Against The Spread + NFL Week 10 Schedule Predictions

For the NFL Week 10 Schedule, we have 28 of the 32 teams playing in 14 games, as we have four teams on a bye week: the Cincinnati Bengals, Dallas Cowboys, Kansas City Chiefs, and Tennessee Titans. We are also back to having international games, with the Colts and Falcons facing off in Berlin, Germany. In the following section, you will find my predictions, with my NFL Week 10 Picks Against The Spread highlighted in bold. All lines are courtesy of DraftKings Sportsbook:

 

 

 

NFL Week 10 Picks Against The Spread: Carolina Panthers -5.5 (-108 at FanDuel Sportsbook)

Last week, I picked the Rams spread against the Saints, despite the fact that it was set at a monstrous 13.5 points. Yet, the Rams covered comfortably, with a 34-10 victory. Are the Carolina Panthers the same caliber of team as the Rams? Well, no, but they are a five-win team coming off an impressive upset over the Super Bowl-contending Green Bay Packers. Now, they get a much lesser challenge, facing off against a one-win Saints team that could not get their rookie quarterback going, nor could they get the run game going to support him. With nothing going on the offensive side of the ball and a defense giving up 27 points per game, I don't understand why the spread isn't at least seven points. Outside of the fact that this is a divisional matchup, which could lead to surprising results, I don't see a world where the Panthers do not cover the 5.5 points. I am taking the Panthers to win with confidence. 

 

 

 

NFL Week 10 Picks Against The Spread: Arizona Cardinals +6.5 (+100 at DraftKings Sportsbook)

Recently, the Seattle Seahawks have looked like one of, if not the best, teams in football. We knew the defense was going to be good under head coach Mike Macdonald, but the offense has really started to gel, led by Sam Darnold. Now, after acquiring Rashid Shaheed from the Saints to reunite with offensive coordinator Klint Kubiak, the rest of the NFC should be scared. So you might be reading this thinking, “Bryan, you're literally taking the Cardinals at +6.5… why?” Well, there is something about this Jacoby Brissett-led Cardinals team…

Since taking over as the starting quarterback, Brissett and the Arizona Cardinals are averaging almost six more points per game. In their last matchup against the Dallas Cowboys, they also had the debut of their 2025 first-round pick, Walter Nolan III, who made an impact on almost every single play he was on the field. He helped hold the explosive Dallas Cowboys offense to a season low of 10 offensive points (the Cowboys' special teams unit blocked a punt for a touchdown to produce their other seven points). These two teams already met once this season, which led to a three-point win for the Seahawks that came down to the wire. This is not the same Cardinals team that they will be facing this time around, so the fact that we are getting a touchdown cushion at plus money is a steal in my eyes. 

 

 

 

How to Bet on NFL Week 10 Picks Against The Spread with Today's DraftKings Promo

Looking to tail our NFL Week 10 Picks Against The Spread? Well, look no further than DraftKings Sportsbook, where you can take advantage of today’s DraftKings promo for the NFL, where you’ll be unlocking a welcome bonus valued at $200 that is completely guaranteed! 

Just sign up now to DraftKings Sportsbook, place a bet $5 or more on one of our picks against the spread (or anything else that you would like), and successful or not, you’ll receive $200 worth of bonus bets! You don’t even have to worry about it winning!

 

 

 

NFL Week 10 Schedule

To make sure you get your NFL Week 10 Picks in before kickoff, we have listed when each game will be played for your convenience:

Thursday Night Football (November 6th, 8:15 PM ET):

  • Raiders vs. Broncos

Berlin Game (November 9th, 9:30 AM ET):

  • Falcons vs. Colts

Sunday, November 9th, 1:00 PM ET:

  • Ravens vs. Vikings
  • Patriots vs. Buccaneers 
  • Jaguars vs. Texans
  • Browns vs. Jets
  • Saints vs. Panthers
  • Giants vs. Bears
  • Bills vs. Dolphins

Sunday, November 9th, 4:05 PM ET:

  • Cardinals vs. Seahawks

Sunday, November 9th, 4:25 PM ET:

  • Rams vs. 49ers
  • Lions vs. Commanders

Sunday Night Football (November 9th, 8:20 PM ET):

  • Steelers vs. Chargers

Monday Night Football (November 10th, 8:15 PM ET):

  • Eagles vs. Packers

Be sure to come back and check out our NFL Week 10 Picks Straight Up, or take advantage of our DraftKings promo by signing up now!