There have been plenty of Thursday Night Football games that have left fans complaining about lackluster matchups, but the start of Week 2 is NOT one of those. We get to enjoy a potential Super Bowl preview with Josh Allen and the Buffalo Bills hosting Jahmyr Gibbs and the Detroit Lions. Those names alone provide enough hype, and we’re here to add to it with our best Lions vs. Bills predictions for TNF Week 2.

We’re also here to add value by going beyond just Lions vs. Bills picks and providing you with a guaranteed 40x DraftKings Sportsbook promo code bonus!

🔥 Lions vs. Bills Predictions for Thursday Night Football, NFL Week 2

Jahmyr Gibbs went extremely early in fantasy football drafts, #1 overall in a ton of cases, and he scored his first TD early for those managers as well. In fact, getting Detroit out to their 7-0 lead made him just the sixth player in NFL history to record 50+ TDs in his first 50 games en route to another two-TD game! As if he needed any more reason to be the focus of Lions vs. Bills predictions.

Of course, he’s not the only one who can punch in rushing TDs, as Josh Allen does even more than many RBs. With so many ways to attack this Week 2 opener, be sure to also check in with our NFL expert picks for more targets. Even if you don’t think this is a Super Bowl preview, you’ll want all the best Lions vs. Bills picks for TNF.

Even some Detroit fans may be doubting that, being the case after the near-collapse against the New Orleans Saints on Sunday. That happened right along with a thrilling 36-31 win for Buffalo, so now that we’ve seen at least something from both teams, let’s get into the best bet from our Lions vs. Bills predictions!

🏅 Lions vs. Bills Expert Pick: Detroit +4.5 Points (-112 at DraftKings)

After seeing Josh Allen score four touchdowns himself and the Lions an overtime two-point conversion away from getting upset, this play may be tough to lock in, but we’re taking the underdog. In fact, those factors are in large part why we’re getting to enjoy this line for our Lions vs. Bills predictions rather than the look-ahead line.

That was UNDER a field goal, and there is no number more key than three when it comes to the spread. We also want to see more from Buffalo before we dub them as AFC favorites without question. There is no doubt that dealing with the Houston defense is incredible, but allowing 31 points to the Texans also factors into our Lions vs. Bills predictions.

The Buffalo defense still has a lot of work to do, and when facing Jahmyr Gibbs + Amon-Ra St. Brown on a short week, that’s a scary prospect. It also doesn’t hurt to note that this is not the same Buffalo home-field advantage that it is in mid-December. We’re also confident that Dan Campbell is going to use their win as more of a learning opportunity than one to be overly excited about.

A Week 1 scare is exactly what will have them fired up and focused to cash the best bet from our Lions vs. Bills predictions for TNF on Detroit +4.5 (-112 at DraftKings).

 

 

 

👀 How To Watch Lions vs. Bills NFL Week 2 Thursday Night Football

With TNF matchups being steamed exclusively, make sure that you don’t miss this one by checking out how to watch Lions vs. Bills Week 2 Thursday Night Football:

  • Where: Highmark Stadium in Orchard Park, NY
  • When: 7:15 PM ET on 9/17
  • Where to stream: Amazon Prime Video exclusively

🔢 Lions vs. Bills Odds, Spreads, Total & Betting Lines

While these are two star-studded teams, we still see that the latest Lions vs. Bills odds for TNF Week 2 at DraftKings Sportsbook favor Josh Allen and Buffalo:

 

 

 

🏉 Lions vs. Bills Injury Report & Latest News

One of the main reasons we targeted Chris Olave vs. Detroit on Sunday is injuries. So, we’ll start there with Lions vs. Bills injuries, as they are without Brian Branch and Kerby Joseph in the secondary. As for the offensive side of things, backup RB Isiah Pacheco is on IR.

Regarding Lions vs. Bills news and injuries in Buffalo, they are largely healthy. They too are without a backup RB in Ty Johnson, as well as a few other backups, but came away unscathed from Week 1.

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