NFL Week 4 features plenty of long traveling with the first-ever game in Ireland, but that holds true even within the states. That’s with Trevor Lawrence and the Jacksonville Jaguars heading across the country to San Francisco to take on Christian McCaffrey and the 49ers, which means that we’ve got our best Jaguars vs. 49ers predictions for Sunday.

Additionally, we’ve also got a guaranteed Sleeper Fantasy promo code bonus on top of our Jaguars vs. 49ers picks, perfect for fans in California without legal sports betting!

Jaguars vs. 49ers Predictions for NFL Week 4, Sunday 9/28

The 49ers fan base is all too used to it by now, while also getting sick of it. That would be injury woes, as not only has it been an issue for a few seasons straight now, but after the recent Brock Purdy injury, we also saw superstar Nick Bosa go down for the year with a torn ACL.

Now, you may be thinking - “oh, it’s just the Jags, who went 4-13 last year.” Well, they’re now 2-1, and frankly, they very well could be 3-0 with their 31-27 loss to the Cincinnati Bengals being the game in which Joe Burrow was injured. All that said, the Jaguars vs. 49ers odds still have San Fran as clear favorites.

Even with the injuries mounting, we’d agree with that assessment, but is that the best way to attack the betting markets? Our Jaguars vs. 49ers predictions say otherwise. 
 

 

 

Jaguars vs. 49ers Best Bet: Brock Purdy Over 243.5 Passing Yards (Use His Player Card At Sleeper)

With these teams not even being in the same conference, let alone division, it’s not a matchup that many fans think about too often. However, it was less than two full seasons ago that these two squads met, and as you’d have guessed, the 49ers jacked up the Jags.

They did so in 34-3 fashion, so while they very well may cover the spread yet again, picking on Jacksonville’s pass defense has been awesome for us dating back to last year and into the past two weeks with Ja'Marr Chase and Nico Collins going off. This time, we’re focused on the QB position rather than a WR.

That may surprise you, given the aforementioned Brock Purdy injury, but we’d take this play whether it was Mac Jones or Purdy, regardless. As for Purdy, he was the starter for that previous meeting, throwing for 296 yards in the process.

Even backup-at-the-time Sam Darnold got snaps, or it could have easily been 300+ passing yards. As for Mac Jones, he’s enjoying being on the opposite coast since leaving the New England Patriots, throwing for 284 and 279 yards the past two games, soaring over his prop line with ease.

The 49ers WR room may not be a topic of conversation, but Ricky Pearsall is coming into his own, and even Christian McCaffrey had 10 receptions last weekend! No matter if it ends up being Mac Jones instead, we have Brock Purdy over 243.5 passing yards (add to a Sleeper DFS lineup) as the best bet from our Jaguars vs. 49ers predictions.
 

 

 

How To Watch Jaguars vs. 49ers NFL Week 4

We said from the start that Jacksonville would be taking a cross-country trip, which you’ll see below regarding how to watch Jaguars vs. 49ers NFL Week 4:

  • Where: Levi's Stadium, Santa Clara, CA
  • When: 4:05 PM ET on 9/28
  • Watch on TV: FOX
  • Where to stream: YouTubeTV, Fubo, Hulu + Live TV

 

 

 

Jaguars vs. 49ers Odds, Spreads, Total & Betting Lines

With CMC and company at home, we see that San Fran is favored in the latest Jaguars vs. 49ers odds for Sunday:

 

 

Jaguars vs. 49ers Injury Report & Latest News

We could have had an entire separate article just for Jaguars vs. 49ers injury news in San Francisco, especially with how significant Nick Bosa's torn ACL is. You’ve seen us refer to others like Brock Purdy, but ones that we haven’t noted is Jauan Jennings and Rickey Pearsall.

Speaking of WRs, we have Jaguars vs. 49ers injury news in Jacksonville with Dyami Brown suffering a shoulder injury this past Sunday. There are always guys beyond the big names, and you can go beyond just Jaguars vs. 49ers injury news with the Fantasy Alarm NFL injury report!  

 

 

 

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