Last week, Thursday Night Football featured an NFC West rivalry with Seahawks vs. Cardinals. Well, Week 5 kicks off in a similar way with Matthew Stafford and the Los Angeles Rams hosting Christian McCaffrey and the San Francisco 49ers. With another NFC West clash on deck, we’ve got our best 49ers vs. Rams predictions for Thursday Night Football.

Making 49ers vs. Rams picks is also perfect with Chalkboard Fantasy thanks to their FREE player pick for the game, being legal in California, AND their multi-part guaranteed welcome bonus!

49ers vs. Rams Predictions For Thursday Night Football, NFL Week 5

The big question heading into the entire season was the health of Matthew Stafford in LA, and heading into this past weekend was if Mac Jones or Brock Purdy would play for the 49ers. In other words, the QB position is where most 49ers vs. Rams predictions will start (don’t miss our premium NFL best bets for Thursday Night Football as well).

With San Francisco being 3-0, getting Purdy back (who cruised over 243.5 passing yards for us) AND hosting a Jacksonville Jaguars team traveling across the country, surely they’re coming into TNF undefeated, right? Well, giving up one of the three punt return TDs we saw in Week 4 was a key part in getting upset, despite those factors. We've also since learned that Brock Purdy is OUT for tonight!

The Rams also had their hands full with a surprisingly 3-0 Indianapolis Colts squad, but got the job done with just a minute left in the game to get to 3-1 for the first time since they won the Super Bowl in 2021. Those results set up this NFC West rivalry with as much anticipation as ever, so let’s get into the best picks from our 49ers vs. Rams predictions.  

 

 

 

49ers vs. Rams Picks: Matthew Stafford Over 0.5 Yards + Kyren Williams Anytime TD (Use In A Chalkboard Lineup)

Two 3-1 teams coming off of two games that came down to the wire truly does set us up for a great TNF matchup, and let’s not forget - it was two NFC West teams (Seahawks vs. Cardinals) last TNF that provided us with a walk-off finish.

Seattle hit our best bet there, and when it comes to making 49ers vs. Rams picks, this game truly could go either way. Matthew Stafford and LA being at home are the favorites, and speaking of hitting best bets, Kyren Williams scored a touchdown for one of our overall weekly plays in Week 3.

He’s found the end zone every other game this season, and he’s due for one against the 49ers. Of course, that “trend” isn’t the only factor. In three career games against San Francisco, the Notre Dame product has FIVE total touchdowns, three on the ground, two through the air.

This past Sunday, the Nick Bosa-less 49ers defense allowed Jacksonville’s Travis Etienne to go off for 124 yards and a touchdown as well. With the standalone odds for a Kyren Williams anytime touchdown being quite pricey, we’d suggest pairing it with the FREE pick at Chalkboard Fantasy of Matthew Stafford over 0.5 passing yards!
 

 

 

How To Watch NFL Thursday Night Football Week 5

TNF has had its featured spot in prime time for as long as most fans can remember, but even still, here’s how to watch 49ers vs. Rams NFL Thursday Night Football Week 5:

  • Where: SoFi Stadium, Inglewood, CA
  • When: 8:15 PM ET on 10/2
  • Where to stream: Amazon Prime Video (exclusively)
     
 

 

49ers vs. Rams Odds, Spreads, Total & Betting Lines

We’ve got two teams that are absolutely both in contention for the NFC West, and the 49ers vs. Rams odds reflect that as well:

 

 

49ers vs. Rams Injury Report & Latest News

We’ve mentioned the biggest 49ers vs. Rams injury news, which is that of Nick Bosa. While his torn ACL isn’t a “new” injury, only being a week removed from it means that it’s still too significant to omit. Of course, we also already mentioned that Brock Purdy is out, and backup Mac Jones will NOT have Ricky Pearsall and Jauan Jennings to throw to tonight.

49ers vs. Rams injury news in Los Angeles was good news in terms of Davante Adams suiting up despite his questionable tag, although Tyler Higbee is doubtful for tonight. San Fran has been plagued with injuries far too often, so be sure to check in with the Fantasy Alarm NFL injury report leading up to TNF!

 

 

 

How To Make 49ers vs. Rams Picks at Chalkboard Fantasy & Claim Several Guaranteed Bonuses w/ Code ALARM

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That’s all yours whether you end up making 49ers vs. Rams picks for those lineups or not! Start reaping the rewards of so much right from the beginning and sign up now using our exclusive Chalkboard promo code ALARM!