As has been the case for a few seasons in a row now, the San Francisco 49ers have perhaps the most injury woes in the entire NFL. Well, they now have a short week as they take on the division rival Los Angeles Rams on TNF. To best enjoy the NFC West rivalry, we’ve hooked you up with our NFL best bets for Thursday Night Football.

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NFL Picks, Predictions & Best Bets for Thursday Night Football, 10/2

Not only are the 49ers dealing with the aforementioned injuries on a short week, but they’re also the ones coming into this NFC West rivalry off a heartbreaking upset loss. Despite hosting the Jacksonville Jaguars with a healthy Brock Purdy, they were unable to advance to 4-0.

Purdy even hooked us up by flying over his 243.5 passing yards prop, and while we didn’t take the same prop for Matthew Stafford, he threw for a whopping 375 yards in the Rams' win over the then-undefeated Indianapolis Colts. Their game went down to the wire as well, but the win means that we have two 3-1 teams featured on TNF. Having said all that, who WON'T be featured tonight is Brock Purdy, among other 49ers.

That makes NFL best bets for Thursday Night Football even more important, so let’s get further into this classic rivalry!
 

 

 

Thursday Night Football Prediction for 49ers vs. Rams 

As great as it can feel to keep things nice and simple with a standard market like we did for last week’s TNF (thank you Seattle Seahawks), we just don’t see the value there for our NFL picks this week. LA may deserve to be favored, but divisional rivalries in prime time can often come down to the wire. The 49ers vs. Rams odds have also shifted so much since the Brock Purdy news that we're now approaching a double-digit point spread! 

We saw exactly that (a tight divisional rivalry) last week as well, but if you're dead set on your NFL predictions for TNF only being on a standard market, there are certainly trends to consider. In the last five meetings between these NFC West rivals, the Rams are 4-1 against the spread, and the over is also 4-1 compared to the under.

However, there is a trend just as glaring for an individual player as well, which leads directly into the top pick from our NFL best bets for Thursday Night Football.

 

 

 

49ers vs. Rams Best Bet for NFL Week 5: Kyren Williams 50+ Rushing Yards & Anytime TD (-110 at Rebet)

Just two weeks ago, Kyren Williams came through for us with an overall best bet of the entire slate by scoring a TD. He did so against the defending Super Bowl champion Philadelphia Eagles, and after what the 49ers just allowed on the ground, we expect him to do so again.

San Francisco allowed Jaguars RB Travis Etienne to run rampant to the tune of 124 yards and a touchdown. Without All-Pro Nick Bosa on the field due to his torn ACL, it isn’t just their pass rush that’s affected. Even if he was, Kyren Williams has proven that he can get the job done against the rival 49ers.

That’s the trend we were referring to. Kyren Williams may not have scored against the Colts, but in his three career games against San Francisco, he has scored five total touchdowns - three rushing and two receiving.

Furthermore, he has had rushing totals of 52, 89, and 108 yards, increasing with each matchup against San Fran. That most recent 100+ performance was even in a 12-6 game, so even if we don’t see another over hit, Williams can still get this done.

If you’re willing to pay the price for just an anytime TD, feel free, but for added value, the NFL best bets for Thursday Night Football are Kyren Williams 50+ rushing yards + an anytime TD (-110 at Rebet).
 

 

 

Top NFL Player Props & Picks for Thursday Night Football, 10/2

If you’d like to add even more NFL picks to our favorite spots, here are some popular 49ers vs. Rams player props being targeted at Rebet Social Sportsbook:

Passing Yards:

Rushing Yards:

Receiving Yards:

Anytime TD Scorer: 

 

 

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