The NBA season tips off on October 22, 2025, with an action-packed 12-game slate showcasing superstars like Victor Wembanyama, Giannis Antetokounmpo, Devin Booker, Zion Williamson, Joel Embiid, and rookie sensation Cooper Flagg. Dive into the 2025-26 season with our top NBA Pick'em selections for these marquee matchups on Sleeper Fantasy HQ!

NBA Sleeper Picks: Wednesday, 10/22; Fantasy Basketball Projections

The 2025-26 NBA season tips off with a bang on October 21, 2025, and now is the perfect time to dive headfirst into the exciting realm of NBA DFS Sleeper Fantasy picks and fantasy basketball projections! 

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Cooper Flagg Sleeper NBA Pick: More Than 12.5 Points (Promo Pick)

We are getting the discount here on the number one overall pick with his points total knocked down to 12.5 for his NBA debut against the San Antonio Spurs.

Flagg comes into the league with much fanfare as a franchise altering talent and he is getting the start at the point guard position this evening.

Flagg can hit all the shots and is a good overall playmaker with the basketball. I'm banking on him announcing his arrival in style here against San Antonio tonight.

 

 

 

Zion Williamson Sleeper NBA Pick: More Than 12.5 Rebounds+Assists

The Pelicans are a very interesting team this season and with a currently healthy and skinny Zion Williamson the expectations are that he comes out and has one of the best seasons of his career.

Zion is a natural playmaker and one that can not just score but also rebound and dish out assists and this Pelicans lineup does have some guys who like to shoot with Trey Murphy and Jordan Poole.

Zion was +260 to record a double-double tonight so the rebound upside is there and if we can get a few assists as well this one should be an easy over.
 

 

 

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Start your journey in daily fantasy sports with our NBA DFS Sleeper Fantasy picks for October 22, 2025! 

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After completing this step, you'll have access to a range of fantasy basketball projections and an additional $50 in bonuses to take advantage of for tonights NBA slate.
 

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