NBA DFS Picks, Projections, Lineups, Injuries & More Today: Wednesday Playbook
Published: Oct 22, 2025
Happy Wednesday, October 22nd, we have a 12-game NBA DFS main slate on DraftKings and FanDuel.
It's the second day of the NBA season and the first big slate of the year with 12 games on the docket. There are a bunch of injuries around the league already and we're going to learn a lot of a lot of teams in game number one.
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Before actually diving into the meat and potatoes, welcome to the NBA DFS season. If this is your first time reading our column on NBA DFS picks, I just want to welcome you and give you a few tips and tricks on what you should be looking for each night.
- News outlets: reliable sources that give us injury news & starting lineups
- Pace of play: who's playing fast vs. who's playing slow. Which teams get a pace-up spot (more possessions) vs. pace-down (fewer possessions)
- Usage rates: is a percentage of how many plays that player is being used in
- NBA DFS Projections
- Lineup Generator
- NBA Ownership
NBA DFS Picks & Daily Fantasy Playbook Today, October 22nd
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Pre/Post-Lock Update
This section will be used for anything that changes from the morning until right up to roster lock.Â
Injury updates, players we’re higher on than we were in the morning and so much more.
All status updates after contest roster lock will be made in the Fantasy Alarm Discord:Â https://discord.gg/2yATJxXe8G
- 2:55 pm ET
- This Karl-Anthony Towns saga today is insane. He was downgraded to doubtful earlier. A report came out he was still going to play and now he's been upgraded to questionable with the intention that he's playing. This hurts everyone involved that isn't named Jalen Brunson.
- Jalen Suggs IS playing for the first time this season. He missed all of preseason, so limit expectations on what the minutes will be.
- Anthony Edwards went through shootaround. Trending towards playing.
- 4:10 pm ET
- Donte DiVincenzo is starting at PG over Mike Conley. Love DiVincenzo's price on FanDuel at just $4.5K.
- Mavericks are going with big lineup w/ Cooper Flagg at PG. That means Flagg - Klay Thompson - P.J. Washington - Anthony Davis - Dereck Lively
- That Dallas lineup could lead to more double big lineups for the Spurs, which would firmly put Luke Kornet in play. They used Kornet-Wemby preseason lineups.
- Ja Morant will not have ANY minutes limit tonight. Firmly puts him in play.
- Players I'm thinking about that didn't make the playbook but could've: Michael Porter, Immanuel Quickley, Walter Clayton Jr. (GPPs), Anthony Davis
- 6:10 pm ET
- With De'Andre Hunter OUT, I'd love it if Jaylon Tyson started in his place.
- Joel Embiid IS on a minutes limit. We don't know the number.
NBA Injuries, News & Updates Today, 10/22
- Giannis Antetokounmpo - IN
- Anthony Edwards - QUEST
- Karl-Anthony Towns - IN
- Domantas Sabonis - OUT
- Jaylen Brown - QUEST
- Paul George - OUT
- Coby White - OUT
- Ty Jerome - OUT
- De'Aaron Fox - OUT
- Josh Hart - OUT
- Scoot Henderson - OUT
- Kel'el Ware - IN
- De'Andre Hunter - OUT
- Jalen Suggs - IN
- OG Anunoby - IN
- Grayson Allen - IN
- Ace Bailey - IN
- Caris LeVert - IN
- Isaiah Collier - OUT
- Daniel Gafford - OUT
- Vince Williams - OUT
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NBA DFS Slate & Game Overviews
In the section below, I’m listing the most notable things we need to look at in Las Vegas, including notable O/U and spreads. Not every game is listed, but every game listed has the pace and defensive numbers listed.
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NBA DFS Core Player Pool & Lineup Picks
Here are the core players I’m looking at for my NBA DFS picks tonight. You can see the full analysis of tonight’s NBA DFS projections and player pool below or skip ahead to building the best lineups possible by locking these into the aforementioned lineup generator now.
High
- Giannis Antetokounmpo, Victor Wembanyama, Cade Cunningham, Devin Booker, Trae Young, LaMelo Ball, Josh Giddey, Anthony Davis
Mid
- Zion Williamson, Jalen Brunson, Kristaps Porzingis, Matas Buzelis
Value
- P.J. Washington (DK), Donte DiVincenzo (FD), Dereck Lively, Jaylen Wells, Tre Jones, Jock Landale, Ace Bailey (FD), Jaylon Tyson, Ryan Kalkbrenner
Don't Miss The NBA DFS Playbook Live Show At 5:00 PM ET
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