After an absolutely incredible Saturday of playoff action - in both the NBA and NHL for that matter - the Boston Celtics gave us the first blowout of the postseason by crushing the Philadelphia 76ers. They’re back on the court again in hours before the series shifts to Philly, so let’s get into our best 76ers vs. Celtics predictions for tonight.

Let’s also take things further than just 76ers vs. Celtics picks by showing you how to claim a GUARANTEED 10x Onyx Odds promo code bonus!

🔥 76ers vs. Celtics Predictions for NBA Playoffs First Round, 4/21

Hopefully, you were locked into our NBA expert picks for Game 1 of this series, as we were on Jaylen Brown going over 24.5 points. Admittedly, it was more of a sweat than it should have been given the blowout, but winning 76ers vs. Celtics predictions are all we care about.

Winning is also all Boston cares about, and they’re favored to do so even more tonight than they were in Game 1. It’s not by much, but there is no reason to believe otherwise in the eyes of the oddsmakers, as Joel Embiid is expected to miss yet another game. For the injury-riddled big man, the appendicitis couldn’t have been unluckier.

On the other side of the injury spectrum, Jayson Tatum continues to amaze after his Achilles tendon tear, looking like it never even happened. Of course, just saying that we expect Boston to win is one thing, but let’s hook you up with some value with the best bet from our 76ers vs. Celtics predictions.

🏅 76ers vs. Celtics Best Bet: Tyrese Maxey Over 26.5 Points (-115 at Onyx Odds)

If Philly is going to pull off the upset, it’s going to need to be on the back of Tyrese Maxey. That’s about the most obvious statement that’s been made so far in 2026, but it’s why we’re focused on him tonight. The line alone provides value for our 76ers vs. Celtics predictions, as it’s often as high as 30.5 or more!

That’s a significant difference, and of course, Boston’s stout defense plays a role in that. Even still, Maxey is capable of 40 or more against any team and on any night, even if it’s just one game of a seven-game series that could end up being meaningless. We also don’t think you should feel hesitation based on Sunday’s final box score.

No star players had to play in the fourth quarter of that game, and frankly, they could have rested starting at halftime. Although in a regular-season game, when Maxey last faced Boston, he went for 33, and better yet, he had 40 and 26 in two of the other three meetings.

Even if Embiid shocks us all with a return, Maxey puts up big numbers even with the center on the court with him. So, we’re going to lock in Tyrese Maxey over 26.5 points (-115 at Onyx Odds) as the best bet from our 76ers vs. Celtics predictions.
 

 

 

👀 How To Watch 76ers vs. Celtics NBA Playoffs First Round

After an afternoon game on Sunday, we’ve got a later tip-off for Game 2, and here’s how to watch 76ers vs. Celtics tonight:

  • Where: TD Garden in Boston, MA
  • When: 7 PM ET on 4/21
  • Watch on TV: NBCSN
  • Where to stream: Peacock

🔢 76ers vs. Celtics Odds, Spreads, Total & Betting Lines

We see Boston slightly more favored and the total slightly higher, and you can see the latest 76ers vs. Celtics odds for tonight at Novig Sportsbook below:

 

 

 

🏀 76ers vs. Celtics Injury Report & Latest News

Once again, the big 76ers vs. Celtics injury is that of Joel Embiid. Also again, he is not expected to be on the court tonight. At least we know that ahead of time, and as for 76ers vs. Celtics injuries in Boston, there aren’t any! Even still, monitor all NBA news with our Fantasy Alarm NBA injury report.

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Yes, that boost is all yours, whether you end up making 76ers vs. Celtics picks or not! So, snag yours in time for everything going on today by 🔗 using this link 🔗 to activate our exclusive Onyx Odds NBA promo code ALARM!