Cavaliers vs. Pistons Predictions, Picks & Odds: NBA on ESPN, 2/27

Tipping off our week is a five-game slate, and what it lacks in volume, it makes up for in quality. Not only do we have an ESPN doubleheader, but it’s also one that features two potential conference championship matchups! The first of which is in the Motor City, which is why we’re here to share our best Cavaliers vs. Pistons predictions for tonight.

As excited as we are to hook you up with our top Cavaliers vs. Pistons picks, we’ve also hooked you up with a guaranteed Onyx Odds promo code bonus! 

🔥 Cavaliers vs. Pistons Predictions for NBA on ESPN, 2/27

If you’ve been sticking with our NBA expert picks this season, and it seems like we just said that the Cavs are in a potential Eastern Conference Finals preview, it’s because we did. It was just the other night that they took down the New York Knicks. Similarly, the Pistons just had some huge matchups.

It was back-to-back potential NBA Finals previews, first losing to the San Antonio Spurs and then bouncing back to beat the defending-champion Oklahoma City Thunder. Both of which were at home, which means that a factor for tonight’s Cavaliers vs. Pistons predictions is Detroit enjoying their third straight home game.

It’s also the third meeting between these top Eastern Conference teams; they met back during the first week of the NBA season and then again in the first week of 2026. They split those meetings, with Cleveland winning the first and Detroit winning the more recent one. Along with recent injuries, let’s find a best bet from our Cavaliers vs. Pistons predictions!
 

🏅 Cavaliers vs. Pistons Best Bet: Duncan Robinson Over 11.5 Points (-115 at Onyx Odds)

One key injury is the one to James Harden of the Cavs. Cleveland went on quite a strong stretch after trading for him from the Los Angeles Clippers, but a thumb fracture threw a wrench in things. Even still, he is questionable tonight, while the other key injury of Donovan Mitchell we already know forces him to be OUT.

As for a Detroit absence that is worth noting for your Cavaliers vs. Pistons predictions, Isaiah Stewart is still suspended. Speaking of the home team, as you can see, that’s where we’re attacking the player prop markets. We thought that the books would finally catch up, but it doesn’t appear as though they have.

We say that because after hitting over 11.5 points in three straight games, five of six, and seven of nine games, we expected an uptick tonight. It would have certainly been warranted, as Cleveland is the fourth-worst team in terms of opposing three-point percentage, and that’s where Duncan lives, making 3+ in four straight games now.

That means that is another viable approach, but we’re sticking with Duncan Robinson over 11.5 points (-115 at Onyx Odds) as the best bet from our Cavaliers vs. Pistons predictions.
 

👀 How To Watch Cavaliers vs. Pistons Tonight

Again, this game tips off the entire slate, so make sure that you won’t miss it and check out how to watch Cavaliers vs. Pistons tonight:

• Where: Little Caesars Arena in Detroit, MI
• When: 7 PM ET on 2/27
• Watch on TV: ESPN
• Where to stream: ESPN+

🔢 Cavaliers vs. Pistons Odds, Spreads, Total & Betting Lines

With a potential Eastern Conference Finals preview on the menu, it shouldn’t be a surprise that the latest Cavaliers vs. Pistons odds for tonight at Onyx Odds suggest a game that could go either way:

• Point Spread: Cleveland Cavaliers +6.5 (-110) vs. Detroit Pistons -6.5 (-110)
• Money Line: Cleveland Cavaliers (+220) vs. Detroit Pistons (-235)
• Game Total (Over/Under): Over 227.5 (-110) vs. Under 227.5 (-110)

🏀 Cavaliers vs. Pistons Injury Report & Latest News

Again, the big Cavaliers vs. Pistons injury to monitor for this matchup is the one to James Harden that caused him to miss Cleveland's game on Wednesday. We say monitor because we don’t have to keep tabs on Donovan Mitchell; he is already out.

As for Cavaliers vs. Pistons injuries in Detroit, they are clean across the board and only have Isaiah Stewart out due to his suspension. Keep track of Harden and much more by bookmarking our Fantasy Alarm NBA injury report!

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