MLB Home Run Picks Today: Best Home Run Predictions for September 15th, 2026
Following a lighter 10-game slate to start the week, we have a full Tuesday on deck to truly enjoy the best MLB home run picks for today. It’s also the first day that we’ve had without football in several days, and we cashed TWO of our top three targets last night! We can certainly do so with Coors Field on the card, as well as Wrigley Field and the Great American Ball Park leading up to it! Of course, we’ve still considered each matchup to ensure that you’re getting the best MLB home run predictions for today!
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⚾ Top MLB Home Run Picks for Today
Along with those prime locations are prime starters like Jacob Misiorowski, Cristopher Sanchez, AND Yoshinobu Yamamoto, who aren’t exactly ideal for MLB home run picks. While you can certainly risk targeting The Miz given that even slightly solid contact can leave the yard, we’d still suggest sticking with our MLB expert picks instead. As always, even if you just want to tunnel-vision MLB home run predictions, you can take advantage of our exclusive MLB home run prop tool!
- Fernando Tatis, Jr.: 21% (+376) at Novig
- Max Muncy: +366 at DraftKings
- Dominic Canzone: 17% (+488) at Novig
🔥 Best Matchups for Home Runs Today, 9/15: Ballpark Factors & Weather Impact
Once again, we have prime locations to target for MLB home run picks during these midweek series. With those including Wrigley Field and its very impactful wind factor, our MLB weather report is a must. Once that is checked, we can start breaking down starting pitchers on the mound and their metrics.
That means everything from righty/lefty splits to barrel and hard-hit rates allowed and plenty of underlying metrics in between. We can name a few of those with the hitters that we also analyze, which include their expected slugging/ISO, average exit velocities and launch angles. Along with bullpens, let’s get into why each of our top MLB home run predictions for today made the cut!
Fernando Tatis, Jr. (+376)
Yes, we led things off with Coors Field yesterday, and yes, we’re heading right back there. Fernando Tatis, Jr. and Manny Machado homered instead of our Jackson Merrill target to keep us from going 3-for-3, so naturally, he’ll go yard instead. Even still, Kyle Freeland and the Colorado Rockies bullpen are great news for cashing multiple MLB home run picks today.
If we’re calling for a guy to hit a homer in back-to-back games, you know it’s a great spot. Coors Field can help anyone hit a homer in every game of a series, and on top of that Freeland has been on the IL for nearly a full month. Even when healthy, he’s not great - he’s allowed a .271 ISO to righties!
Combined with Tatis’ .261 ISO vs. lefties, we’re leading off our best MLB home run picks for today with Fernando Tatis, Jr. hitting a HR (21%, so +376, at Novig).
Max Muncy (+366)
We’ll once again note Sugano here, because today, we’re enjoying our second-favorite trio! That would be Rhett Lowder, the Cincinnati Reds bullpen, and the Great American Ball Park. We also saw a Dodgers vs. Reds matchup in LA last week, so we’re right back to it. Will Smith cashed one of our MLB home run picks, so who do we target tonight?
Well, Lowder - a righty - allowed a .204 ISO to lefties, and against the star-studded Dodgers, that means a classic pick-your-poison situation. That said, Shohei Ohtani has been banged up in multiple ways, and Freddie Freeman has had one of his colder stretches. So, we’re right back to another LA hitter that has come through for us recently, like Smith.
You’ve already seen the name, so yes, we’re continuing our best MLB home run picks for today with Max Muncy hitting a HR (+366 at DraftKings).
Dominic Canzone (+488)
Cal Raleigh’s bat awakening once again went yard last night, and we recently saw Randy Arozarena double dong. So, as inconsistent as the Seattle Mariners lineup can be, it only takes one for dingers. They should also enjoy being at Angel Stadium rather than at home, and the Los Angeles Angels bullpen is also great for MLB home run picks.
Even before we get to that part of the game, starter Ryan Johnson allows power to both sides of the plate. That said, as you can see, we’re rolling with a lefty that has plenty of power himself. We’re talking about a .226 ISO vs. righties to pair with Johnson’s .203 ISO allowed to southpaws. It’s a perfect combo to add to our best MLB home run picks for today with Dominic Canzone hitting a HR (17%, so +488, at Novig).
🎯 Newsletter Exclusive Pick 🎯
Our top home run picks are above, but we also included one bonus HR play exclusively in today's edition of The Daily Alarm. If you're subscribed, don't forget to check your inbox before lock. If not, sign up for free to get these extra and exclusive picks daily!
🚀 Longshot Home Run Picks Today
Going from a lighter slate to a jam-packed evening means that we need to go even further with our best MLB home run picks for today, which means our favorite longshot option…
This is far from our longest of longshots, but this price just doesn’t seem right. Sure, he’s not Yordan Alvarez, but he has stretches where he’s hitting more HRs than him, and now he gets the Kansas City Royals bullpen, and starter Michael Wacha has a .254 ISO allowed to righties!
💲 Today’s Best MLB Home Run Parlay
You can certainly combine our top three targets into a for-fun parlay for even more added value; however, if you want more names to consider here’s how we’re adding to our top MLB home run picks today…
As you’ve come to expect, we’ve got some pivots from our top three targets for you! After all, they’re all more than capable of going yard in the same matchups. So, take advantage of our top MLB home run picks today, however you’d like!
