The 2026 college football season rolls on! Saturday’s matchup between the Miami Hurricanes and Notre Dame Fighting Irish headlines CFB Week 10. That means it’s time to dive into #1 Miami vs. #4 Notre Dame predictions before kickoff. We’ll preview the game, break down the matchup, and dish out expert #1 Miami vs. #4 Notre Dame picks. Plus, get to know the latest #1 Miami vs. #4 Notre Dame odds ahead of Saturday’s showdown.
#1 Miami vs. #4 Notre Dame Predictions for CFB Week 10, Saturday 11/7
Before we get to our #1 Miami vs. #4 Notre Dame predictions, let’s set the stage for Saturday’s game. Notre Dame enters as a 7.5-point home favorite with a 54.5 over/under on BetMGM Sportsbook. The Fighting Irish are 7-1 this season, with their only loss at BYU two weeks ago. The Hurricanes are undefeated and first in the latest College Football Playoff rankings.
Without further ado, let’s dive into our #1 Miami vs. #4 Notre Dame picks. There’s a certain betting angle worth locking in before Saturday’s matchup kicks off. Good luck!
#1 Miami vs. #4 Notre Dame Expert Pick: Notre Dame Team Total Over 31.5 Points (-102 on BetMGM Sportsbook)
Miami star wide receiver Malachi Toney is expected to miss this game with an ankle injury. It’s a massive blow to the Hurricanes ahead of their clash against Notre Dame. Instead of worrying about the spread or total, let’s just focus on the Fighting Irish offense for our #1 Miami vs. #4 Notre Dame predictions.
Notre Dame boasts one of college football's top offenses. The Irish are averaging 40.4 points per game, ranking 5th-most in the country. They’re also 6th nationally in offensive EPA/Play and 3rd in offensive success rate. This high-powered attack is a force to be reckoned with, and it should set the tone at home in this matchup.
Miami’s defense has shown some cracks in recent games. The Hurricanes just gave up 35 points and 407 total yards to North Carolina last week. They also allowed 35 and 23 points to Florida State and Pittsburgh, respectively, in the two games prior. In both matchups, the ‘Canes coughed up 400+ total yards as well.
These are concerning stats for a defense that previously rolled through the easier part of its schedule. Notre Dame has a much better offense than all three of those opponents, and it can exploit Miami’s defensive issues. The Irish have scored at least 35 points in 6 of 8 games this season. They can do it again this week.
Notably, Miami has struggled to defend the pass. The Hurricanes rank 110th in defensive EPA/Pass and 103rd in defensive success rate vs. the pass. That could be trouble against Notre Dame, which ranks 4th nationally in both passing success rate and EPA/Pass. Quarterback CJ Carr and his slew of playmaking receivers should gash this Miami defense.
So, take the over on the Irish team total for our #1 Miami vs. #4 Notre Dame predictions. BetMGM Sportsbook has it set at 31.5 points. Again, Notre Dame has cleared this in 6 of 8 games this season. In the two outliers, the Irish scored 27 and 24 points.
How To Watch #1 Miami vs. #4 Notre Dame CFB Week 10
- Date: Saturday, November 7, 2026
- Time: 7:30 PM ET
- Location: Notre Dame Stadium, South Bend, Indiana
- TV: NBC
#1 Miami vs. #4 Notre Dame Odds, Spread, Total & Betting Lines
After #1 Miami vs. #4 Notre Dame predictions, let’s take a look at the betting lines for this college football matchup. Here are the latest #1 Miami vs. #4 Notre Dame odds from BetMGM Sportsbook ahead of Saturday’s showdown.
- Spread: Miami +7.5 (-115) | Notre Dame -7.5 (-105)
- Moneyline: Miami +225 | Notre Dame -275
- Over/Under: 54.5 (Over -112 | Under -105)
#1 Miami vs. #4 Notre Dame Injury Report & Latest News
Miami Hurricanes:
- WR Malachi Toney – Out
Notre Dame Fighting Irish:
- DT Jason Onye – Questionable
- DT Francis Brewu – Questionable
- DB Brauntae Johnson – Out
- DL Christopher Burgess Jr. – Out
- DL Tiki Hola – Out
- OL Charles Jagusah – Out
- OL Chris Terek – Out
- CB DJ McKinney – Out
- LB Drayk Bowen – Out
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