Best NFL DFS Week 10 Picks & Watch List: Top DraftKings & FanDuel Plays
Published: Nov 05, 2025
After the absolute bonanza we celebrated last week, I know you're ready to start digging into our NFL DFS Week 10 picks. It's easy to get amped up after such a strong week, but we contain our emotions and we stick to the process. Cash games are a thing of the past unless you're playing head-to-head contests. We focus on single-entry GPP tournaments. And our process stay the same. We read everything here on Fantasy Alarm first – DFS positional coaches, WR/CB Match-Up Report, NFL game previews, etc. We stay on top of all the latest NFL news, especially since we just had the NFL deadline, and then we dive into the DFS Watch List as we prepare our player lists and finalize our NFL DFS Week 10 picks.
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Usually here is where I start discussing how we've adjusted our strategy; how we made our midseason adjustments to our lineup construction and contest selection. I don't think there's a need right now. Most of you have been with us from Week 1 and have read all about the strategic transformation. If you are new to the #FAmily, welcome, but you don't need for us to rehash yesterday's news. We move onward and we start taking down bigger money for ourselves. Maybe we don't have as strong a week as we just had, but if you're following the process, doing the research on your own and asking the questions you need to be asking, we're all going to enjoy one heck of a second half to the NFL season.
Before we get to the NFL DFS Week 10 picks, I always like to present to you the optimal lineups that could have been build just using the DFS Playbook and Dart Board.Â

While the rest of the world was loading up on the Buffalo Bills/Kansas City Chiefs and Cincinnati Bengals/Chicago Bears games, we pointed out some crucial plays that also went wildly under-owned. Caleb Williams was a chalk play which is fine so long as he delivers, but using Drake London's three-score game was the biggest hit that no one else was on. Using Kyren Williams and Christian McCaffrey with the value of Kyle Monangai was also huge for us. And come on – Jameson Williams? No one had him. I don't want to get caught up in pounding my chest more, but this is what the midseason adjustments are all about.
So are you ready to get to our NFL DFS Week 10 picks we're watching? Let's do it!
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