Need the best Splash Picks NFL picks today? Week 5's Sunday slate features a Seahawks lead back with a wide-open path to volume and a Raiders quarterback facing a Patriots secondary down four cornerbacks. Below, we cover our favorite Splash Picks NFL picks for this Week 5 slate, backed by player projections and the key matchups shaping each pick.

 

49ers vs. Seahawks and Raiders vs. Patriots: Game Outlook & Key Matchups

Seattle hosts a 49ers team without Nick Bosa, Emanuel Wilson is the clear lead back with Jadarian Price on injured reserve and Zach Charbonnet out; and Kirk Cousins and the Raiders face a Patriots secondary that has ruled out four cornerbacks. Both matchups feature injury-driven opportunity for the players we like. Let's break down the Splash Picks plays we like most for this slate.

Best Splash Picks NFL Picks for Sunday, Week 5

Emanuel Wilson NFL Splash Picks Pick: Higher 59.5 Rushing Yards

Wilson has handled 21 carries in two of Seattle's first four games, rushing for 92 and 81 yards in those outings, and his path to another big workload is wide open this week. Price is on injured reserve until at least Week 8, Charbonnet is out, and last week Wilson took 76% of the team's backfield opportunities, including 21 of 28 running back carries. San Francisco will be without Bosa, Thompson, and Sigle, while Mykel Williams returns from an ACL injury and may be limited. With the Seahawks favored at home, Wilson should see plenty of early-down work and clock-killing carries, which makes 59.5 rushing yards a very reasonable number.

Kirk Cousins NFL Splash Picks Pick: Higher 224.5 Passing Yards

Few quarterbacks have been better than Cousins to start the year, with 1,026 yards, 11 touchdowns, and a 64.6% completion rate through four games. New England is down four cornerbacks this week, including Gonzalez and Davis III, and that is a significant problem against a quarterback who just threw for 365 yards on 52 attempts. Las Vegas is a 3.5-point road underdog, a script that should keep Cousins throwing, and the weather looks manageable with only light wind in the forecast. A veteran averaging 256.5 yards a game, clearing 224.5 looks like a strong bet.

 

Splash Picks NFL Player Projections for Week 5 Sunday

Both of these plays lean on the same framework behind Fantasy Alarm's Weekly Player Projections, which generates a projected stat line for every player on the slate by weighing expected pass and rush volume, touchdown probability, and matchup context rather than just last week's box score. That's the same process that pointed us toward Wilson and Cousins as our top plays for Sunday, and it refreshes throughout the week as news, weather, and depth charts shift. Fantasy Alarm All Pro members get the full weekly breakdown for every player in every game, not just the two we're highlighting here. If you want the complete picture behind every Splash Picks pick we make, upgrading to All Pro is the fastest way to get it.

How to Play These Splash Picks NFL Picks With Promo Code ALARM & Get Over $50 in Bonuses

Ready to build an entry around these picks? Sign up for Splash Picks with promo code ALARM and unlock over $50 in bonuses to get started. Just create an account, make a qualifying deposit, and the bonus offers apply automatically - no extra steps needed. Check out all of Fantasy Alarm's active offers for even more ways to load up on extra plays around a Week 5 Sunday slate that's already stacked with value.