As Week 12 of the 2025 NFL season culminates under the bright lights of Monday Night Football, the San Francisco 49ers (7-4) roll into Charlotte to battle the Carolina Panthers (6-5) in a cross-conference showdown ripe with playoff implications and individual breakout potential. The high-octane 49ers offense, spearheaded by quarterback Brock Purdy's precision passing and running back Christian McCaffrey's dual-threat dominance, aims to exploit a Panthers defense that's shown flashes of resilience but struggled against elite attacks. Meanwhile, Carolina's young gunslinger, Bryce Young, looks to build momentum after his career game, setting the stage for intriguing player props on yards, touchdowns, and more. Let's break down the best bets to elevate your wagering game tonight.

 

 

 

Best NFL Monday Night Football Player Prop Picks: Bryce Young Over 210.5 Passing Yards

Young is building momentum after a franchise-record 448-yard outburst last week. Tonight, he faces a 49ers secondary that's been porous, allowing nearly 300 passing yards per game lately. Utilizing a healthy Tetairoa McMillan, who had eight catches for 130 yards last week, and Xavier Legette, who finished with four catches for 83 yards, Young should be set up for another strong game where the Panthers will lean on the pass as home underdogs.

 

 


 

49ers vs Panthers Player Props: Christian McCaffrey Over 72.5 Rushing Yards

The 49ers' ground game is built around McCaffrey, who remains a cornerstone of their offense. He's cleared this rushing yardage in two of his last three starts and three of his past five. Carolina's run defense has struggled, yielding over this total to starting RBs in four straight games. In a matchup where San Francisco is favored, McCaffrey should feast, easily surpassing 72.5 yards with a heavy workload.

 

 

 

49ers vs Panthers Player Prop Bets: George Kittle Over 4.5 Receptions

Kittle thrives against defenses like Carolina's, which sits at the bottom of the league in DVOA versus tight ends. Their zone-heavy scheme with two-high safeties exposes the middle, perfect for Kittle's route-running. He's a key target for Brock Purdy, and this prop feels like a lock.

 

 

 

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