If there was one team that garnered the most attention since the 2025 NFL Draft, it’s the Cleveland Browns. That’s thanks to the selection of QB Shedeur Sanders, and we now have the first chance to see if he’ll actually take the field. With their preseason opener featured on NFL Network, we’ve got our best Browns vs. Panthers predictions for you.

DraftKings Sportsbook is also ready for the NFL season with their brand new, guaranteed welcome offer, and we'll also be sharing those details to add value to any Browns vs. Panthers picks!

Browns vs. Panthers Predictions For NFL Preseason, Friday 8/8

Locking in any best bets for the NFL preseason is a tall task, as these games have so many more variables than regular-season games. That includes simply knowing who is going to take the field, but even still, we’ve got Browns vs. Panthers predictions for you.

Truthfully, all of the focus is going to be in Cleveland these days with the aforementioned Shedeur Sanders. While we almost never truly know 100% the amount each player will see the field, head coach Kevin Stefanski at least provided us with an official QB depth chart earlier in the week.

That was topped by a 40-year-old Joe Flacco and followed by Kenny Pickett at #2, Dillon Gabriel (also a rookie; drafted ahead of Sanders) at #3, and Shedeur Sanders at the #4 spot. Despite that news early on Tuesday, by late afternoon that same day, we were told that Shedeur Sanders would be the starter!

Not to completely ignore the Carolina side of the matchup, we’ve seen tons of positive news about a different rookie - Panthers WR Jimmy Horn Let’s not forget that he’s a former teammate of Shedeur Sanders at Colorado, and the sixth-round pick has been using his elite speed to make waves during training camp.
 

 

 

Browns vs. Panthers Best Bet: Under 32.5 Points (-105 At DraftKings)

Come regular season time, you can be sure that Browns vs. Panthers player props will be a popular target, especially given Shedeur Sanders' involvement. Until then, we’re limited in terms of betting market types to target.

While that may mean the standard lines, we still love the sound of a low-scoring game. As if Cleveland having as much drama in the QB room as a reality TV show wasn’t enough reason, it’s also not like the Panthers are a team that can pounce at the opportunity to show off elite play under center.

Dave Canales was hired as the Panthers' new head coach two offseasons ago to be a QB whisperer for young Bryce Young. While he looked to make strides at times, the Alabama product still finished the season with an average QBR of 54.1.

All that is worth noting because Canales has decided to change his preseason approach. After not playing starters until the final week of it last year, he has stated that starters, like Young, will play a series a two to simulate specific situations. With starters getting some snaps, surely that means more points, right?

If anything, it’s only going to take away time from backups getting in a rhythm to try and prove themselves. The same can be said regarding the Browns, as they may end up with four different QBs taking snaps.

It may not be the more fun approach to root for, but the best bet from our Browns vs. Panthers picks is the under 32.5 points (-105 at DraftKings Sportsbook).
 

 

 

How To Watch Browns vs. Panthers NFL Preseason Week 1

For a Friday night of NFL preseason action, this is the lone matchup on NFL Network, and you can see more regarding how to watch Browns vs. Panthers NFL Preseason Week 1 below:

  • Where: Bank of America Stadium in Charlotte, North Carolina
  • When: 7 PM ET on 8/8
  • Watch on TV: NFL Network
  • Where to stream: NFL+, Hulu + Live TV

 

 

 

Browns vs. Panthers Odds, Spreads, Total & Betting Lines

Of course, you’ll also want the latest lines, so you’ll see the current Browns vs. Panthers odds at DraftKings Sportsbook below:

 

 

Browns vs. Panthers Injury Report & Latest News

While Carolina coach Dave Canales is planning to give starters some time, anyone even remotely part of the Browns vs. Panthers injury news won’t be risked. That means guys like WR Hunter Renfrow and TE Tommy Tremble.

As for the latest Browns vs. Panthers news in Cleveland, it remains in the QB room, as both Kenny Pickett and Dillon Gabriel have been limited in practice this week. Perhaps that has helped Shedeur Sanders leapfrog them into getting the start on Friday night. Regardless, always stay up to date with the Fantasy Alarm NFL injury report!

 

 

 

How To Bet On Browns vs. Panthers At DraftKings Sportsbook & Claim Your $200+ Bonus

Cleveland and Carolina both get to enjoy legal sports betting, not to mention a ton of other locations at this point, and the brand new DraftKings sign-up bonus is a must-have:

  1. Sign up here for a new DraftKings account
  2. Make a first-time deposit of $5 or more
  3. Place a wager of $5+ on anything - not just the Browns vs. Panthers odds 
  4. Receive $200 in bonus bets AND $200 off NFL Sunday Ticket - even if it loses! 

Two guaranteed bonuses is generous enough, let alone ones that are a 40x bankroll boost and one perfect for the NFL season! You also won’t even need to enter a DraftKings promo code when you create a new account through us!