Welcome to our 2026 NFL Week 6 Picks Straight Up! Our first hiccup since the season started occurred last week, with the Raiders ruining our shot at yet another sweep of our featured picks. Like I said to begin the week, it was a tougher slate to predict. Today, though, I am feeling REALLY good about some of these games.
So, without further ado, it is time to bring you our expert 2026 NFL Week 6 Picks Straight Up. Below, you will find my picks, some highlighted matchups, and the odds and spreads for every game this week.
2026 NFL Week 6 Picks Straight Up for All 14 Games
With Week 6 here, we have some great matchups on paper and some more bye weeks! The Cincinnati Bengals, Detroit Lions, Miami Dolphins, and Minnesota Vikings get some much-needed rest this week, leaving 28/32 teams in the Week 6 schedule. In the following section, you will find my predictions, with the teams I anticipate coming away with a victory highlighted in bold. Odds are courtesy of BetMGM:
| Matchup | Moneyline Odds |
| Seattle Seahawks at Denver Broncos | SEA -160 / DEN +130 |
| Houston Texans vs. Jacksonville Jaguars (London) | HOU +124 / JAX -148 |
| Chicago Bears at Atlanta Falcons | CHI -178 / ATL +149 |
| Baltimore Ravens at Cleveland Browns | BAL -225 / CLE +190 |
| Tennessee Titans at Indianapolis Colts | TEN +263 / IND -325 |
| New York Jets at New England Patriots | NYJ +284 / NE -357 |
| New Orleans Saints at New York Giants | NO -105 / NYG -115 |
| Carolina Panthers at Philadelphia Eagles | CAR -110 / PHI -108 |
| Pittsburgh Steelers at Tampa Bay Buccaneers | PIT -149 / TB +125 |
| Arizona Cardinals at Los Angeles Rams | ARI +596 / LAR -877 |
| Los Angeles Chargers at Kansas City Chiefs | LAC +340 / KC -439 |
| Buffalo Bills at Las Vegas Raiders | BUF -275 / LV +225 |
| Dallas Cowboys at Green Bay Packers | DAL -105 / GB -115 |
| Washington Commanders at San Francisco 49ers | WAS +328 / SF -424 |
NFL Week 6 Picks Straight Up: Carolina Panthers ML (-104 at FanDuel Sportsbook)
As I mentioned last week, the Philadelphia Eagles look broken. Yes, they almost upset the Jacksonville Jaguars last week, with Jalen Hurts playing fairly well and the defense looking like the dominant unit that it was last season, but coaching is still an issue. Despite the Jaguars having 100 yards in penalties, they could not overcome the coaching deficiencies that have been present throughout the Sirianni Era.
Meanwhile, after dealing with several early injuries, the Carolina Panthers come off a much-needed bye week ready to take on Philly. Even without their top two corners, this offense has been doing enough to make up for a banged-up defense. Tetairoa McMillan is fresh off a career day, Jalen Coker should be back from injury, and as long as the two marquee free agent signings on defense, Jaelen Phillips and Devin Lloyd, are good to go, I trust this team to hand the Eagles yet another loss. I love the price point we are getting this one at, and I will back the Panthers with confidence.
NFL Week 6 Picks Straight Up: Jacksonville Jaguars ML (-134 at FanDuel Sportsbook)
This one is fairly simple to me. The Jaguars have played back-to-back games in London twice (once in 2023 and once in 2024). Both times, they have won outright, with a 25-20 win over the Buffalo Bills in 2023 and a 32-16 win over the New England Patriots in 2024. While I believe the Houston Texans are on the rise, they are going against a team that is not only incredibly talented, but a week ahead of them in terms of getting acclimated to international travel as well.
Despite the Jaguars’ clear struggles against Jalen Carter on the defense and overall discipline, I think another week in their “home away from home” will help them settle in and look more like the juggernaut they have appeared to be throughout the rest of the NFL season thus far. I am expecting a close game, but I like the Jaguars to pull off the divisional win here.
2026 NFL Week 6 Odds & Spreads For All 14 Games
We just unveiled our 2026 NFL Week 6 picks, and below are the spread odds for each matchup, provided by BetMGM Sportsbook:
| Matchup | Spread Odds |
| Seattle Seahawks at Denver Broncos | SEA -3 / DEN +3 |
| Houston Texans vs. Jacksonville Jaguars (London) | HOU +2.5 / JAX -2.5 |
| Chicago Bears at Atlanta Falcons | CHI -3 / ATL +3 |
| Baltimore Ravens at Cleveland Browns | BAL -4.5 / CLE +4.5 |
| Tennessee Titans at Indianapolis Colts | TEN +7 / IND -7 |
| New York Jets at New England Patriots | NYJ +7.5 / NE -7.5 |
| New Orleans Saints at New York Giants | NO +1.5 / NYG -1.5 |
| Carolina Panthers at Philadelphia Eagles | CAR +1.5 / PHI -1.5 |
| Pittsburgh Steelers at Tampa Bay Buccaneers | PIT -2.5 / TB +2.5 |
| Arizona Cardinals at Los Angeles Rams | ARI +12.5 / LAR -12.5 |
| Los Angeles Chargers at Kansas City Chiefs | LAC +8.5 / KC -8.5 |
| Buffalo Bills at Las Vegas Raiders | BUF -6 / LV +6 |
| Dallas Cowboys at Green Bay Packers | DAL +1.5 / GB -1.5 |
| Washington Commanders at San Francisco 49ers | WAS +7.5 / SF -7.5 |
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