The San Francisco 49ers and Los Angeles Rams feature some of the top fantasy football picks, from Christian McCaffrey to Puka Nacua and several guys in between, so having them featured on the first Thursday Night Football game is as ideal as it gets…and it’s in Australia! Even if you don’t have CMC, Matthew Stafford, or the like on your fantasy squad, we’re here to help make 49ers vs. Rams as exciting as possible with our NFL best bets for Thursday Night Football.

They could also help you fantasy-wise, and what will certainly help your NFL picks for TNF is something else that we’ve also broken down - a generous $1,000 Fanatics Sportsbook promo code bonus!

🔥 NFL Week 1 Thursday Night Football Best Bets, Expert Picks & Predictions for 49ers vs. Rams, 9/10

Along with the fantasy football studs noted above, we also have to remember that both defenses in this matchup can’t be ignored. Aaron Donald coming out of retirement to pair with the huge LA addition of Myles Garrett this offseason is huge, and a healthy Fred Warner for San Fran also affects NFL predictions for TNF.

While there are notables for both sides, it’s the Rams that are both favored for this game and the favorites to win the Super Bowl. In fact, it’s quite the gap between them (+500) and the next-closest teams at +1000. That will have many fans backing them with their NFL best bets for Thursday Night Football, and you can see if we did with our overall 49ers vs. Rams predictions.

However, with no new data to analyze for this season, you may not want to trust either team to come out victorious, cover a spread, or the like. Thankfully, unlike the preseason, there are countless player props to consider, and we’ve locked one of those in with the top pick from our NFL best bets for Thursday Night Football.

 

 

 

🏉 49ers vs. Rams Best Bet for NFL Week 1: Matthew Stafford Over 261.5 Passing Yards (-115 at Fanatics)

A healthy Fred Warner should have 49ers fans excited, but overall, they are once again a team that is quite banged up. Their defense, especially, has guys with concerns at every level, and we’ve already seen that the reigning MVP can handle this familiar foe. In their two meetings last season, Stafford averaged 334.5 passing yards per game.

The first of which actually cashed some NFL best bets for Thursday Night Football, as these NFC West rivals met on TNF of Week 5. The game going to OT helped the Rams QB get to 389 passing yards, so while that average was carried by that game, he still had 280 in the other. He still has his two key weapons of Puka Nacua and Davante Adams, so the chemistry is there to do it again.

It’s also not just the reigning MVP who was able to exploit this San Fran defense. While they have become known for their stout D over the past handful of seasons, against the pass last year, it was anything but. They allowed the eighth-most passing yards per game, and again, several secondary guys are entering the season with questionable tags.

That’s not what any team wants to see, especially against a seasoned veteran, so we’re locking in Matthew Stafford over 261.5 passing yards (-115 at Fanatics) as the top pick from our NFL best bets for Thursday Night Football.

🔢 Best NFL Player Prop Bets & Picks Today for Thursday Night Football

Ready to take things a step further with more NFL picks for TNF? Here are some of tonight’s most popular 49ers vs. Rams player props at Fanatics Sportsbook:

Anytime Touchdown:

  • Deebo Samuel: +330
  • Davante Adams: +140

Passing Yards (Over/Under):

  • Brock Purdy: Over 244.5 (-126) vs. Under 24.5 (-105)
  • Matthew Stafford: Over 261.5 (-115) vs. Under 261.5 (-115)

Rushing Yards (Over/Under):

  • Christian McCaffrey: Over 59.5 (-126) vs. Under 59.5 (-105)
  • Kyren Williams: Over 56.5 (-115) vs. Under 56.5 (-115)

Receiving Yards (Over/Under):

  • Mike Evans: Over 48.5 (-126) vs. Under 48.5 (-105)
  • Puka Nacua: Over 90.5 (-115) vs. Under 90.5 (-115)

 

 

 

📊 Fantasy Alarm NFL Best Bets Record 

We’ll be making NFL predictions all season to expand on last year’s success, and speaking of which, you can see our final record from the 2025-26 season below:

  • Overall record: 427- 390
  • Units: 102.72u
  • ROI: 11.72%

💲 How to Make NFL Best Bets for TNF at Fanatics & Claim Your $1,000 Bonus w/ Code ALARMFAN

We promised a way to make our NFL best bets for Thursday Night Football (and your own picks) even more valuable, so here’s how to nab today’s huge $1,000 Fanatics promo code bonus:

  1. Click here 👈🏼 to create a new Fanatics account
  2. Enter our exclusive Fanatics NFL promo code ALARMFAN
  3. Make a deposit of at least $10
  4. Place a wager of $1+ on any market with odds of -500 or longer on day one
  5. If the wager loses, receive up to $100 in FanCash within 72 hours
    1. Repeat every day for 10 consecutive days to earn up to $1,000 in total FanCash!

Given their unique, platform-specific funds, this is an offer like no other, so don’t miss out and sign up today ☀️ with no actual Fanatics promo code required, thanks to our links!