Getting to start the NFL season with a Super Bowl rematch is ideal, and following it up with an NFC West rivalry on Thursday Night Football is the perfect follow-up. Not only are Christian McCaffrey and the San Francisco 49ers divisional rivals with Matthew Stafford and the Los Angeles Rams, but they’re also in-state rivals; that said, don’t forget - this matchup is in Australia! Such a unique matchup is why having our best 49ers vs. Rams predictions for TNF is an absolute must.

To make Thursday Night Football even more exciting AND valuable, we’ll go beyond just 49ers vs. Rams picks for TNF and share a GUARANTEED DraftKings Sportsbook promo code bonus:

🔥 49ers vs. Rams Predictions for Thursday Night Football, NFL Week 1

This NFC West rivalry being in Australia isn’t the only storyline; it wasn’t too long ago that we learned that Aaron Donald was coming out of retirement to join the Rams! While that isn’t enough to move the needle in terms of the 49ers vs. Rams odds, it has had fans dubbing LA as the closest thing the NFL can get to a super team.

Unfortunately for San Francisco fans, it’s already a chapter that’s been written before - injuries are a concern. However, they’ve always found a way to overcome them, and in fact, for both meetings against LA last season, 49ers vs. Rams predictions were made with Mac Jones under center rather than Brock Purdy.

Of course, we can’t gloss over the fact that at the age of 37 (he turned 38 the day after the Super Bowl), Matthew Stafford won the MVP. So, should LA really be Super Bowl favorites as one of the oldest teams in the NFL? Well, perhaps the best bet from our 49ers vs. Rams predictions will help answer that!

🏅 49ers vs. Rams Expert Pick: Los Angeles -3.5 (-108 at DraftKings)

Ok, it’s far too early to label the Rams as shoe-ins for the Lombardi Trophy, but we do have them winning this matchup down under by more than a field goal. You can get three at some spots as well, which is helpful by giving you the push condition. Regardless, we’re taking the stacked roster with our 49ers vs. Rams predictions.

Is a core of aging veterans a potential concern? Of course. However, this is Week 1, and those ailments haven’t risen yet, so we’re riding with what is a roster with strong players at every position. Whether it’s the reception and yardage beast of Puka Nacua, redzone TD threat of Davante Adams, or worse horse of Kyren Williams, they have it all.

Oh yeah, that’s without mentioning the defense that impacts 49ers vs. Rams predictions. Sure, San Fran will have a healthy Fred Warner, but they’re banged up just about everywhere else. Meanwhile, in addition to the Aaron Donald return, they also added Myles Garrett to further bolster their already stout defense.

Divisional rivalries can always make things more interesting, but we’re still comfortable locking in LA -3.5 (-108 at DraftKings) as the best bet from our 49ers vs. Rams predictions for TNF.

 

 

 

👀 How To Watch 49ers vs. Rams NFL Week 1 Thursday Night Football

Even if you’ve gotten used to TNF being streamed in just one location, we’ve got you covered with how to watch 49ers vs. Rams NFL Week 1 Thursday Night Football, especially with the Australia action:

  • Where: Melbourne Cricket Ground, Melbourne, VIC, AUS
  • When: 7:35 PM ET on 9/10
  • Where to stream: Amazon Prime Video exclusively

🔢 49ers vs. Rams Odds, Spreads, Total & Betting Lines

For this divisional and in-state rivalry, you’re going to want any and all info regarding it, so here are the latest 49ers vs. Rams odds for TNF at DraftKings Sportsbook:

 

 

 

🏉 49ers vs. Rams Injury Report & Latest News

Among the biggest 49ers vs. Rams news is Aaron Donald, as he'll be traveling to Australia, but whether he plays in this game or not remains uncertain. Speaking of which, San Francisco traveled down under well before Los Angeles. As for actual 49ers vs. Rams injuries, most lie with San Fran.

We know that George Kittle is working his way back to 100%, but they have a ton of guys with questionable tags: Christian McCaffrey, Mike Evans, De'Zhaun Stribling, Kyle Juszczyk, Nick Bosa, and oh yeah, Rickey Pearsall and Christian Kirk are on IR. We're going to be keeping tabs of a ton of 49ers vs. Rams injuries for SF leading up to kickoff.

Beyond Aaron Donald, LA has Puka Nacua and Myles Garrett with questionable tags, but both are expected to be good to go.

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