NFL primetime games often feature divisional rivalries, but to close out the Week 6 slate, we’ve got a cross-country clash with the San Francisco 49ers hosting the Washington Commanders. The QB position alone provides plenty of intrigue with Jayden Daniels trying to stay healthy and Brock Purdy being in the MVP conversation. Even if this isn’t a likely playoff preview, we can still make it just as exciting with our NFL best bets for Monday Night Football!

Better yet, we’ll make it even more exciting with how to enjoy a GUARANTEED $200+ DraftKings Sportsbook promo code bonus for far more than just NFL picks!

🔥 NFL Week 6 Monday Night Football Best Bets, Expert Picks & Predictions for Commanders vs. 49ers, 10/19

Not only is Brock Purdy rivaling Josh Allen in terms of the MVP odds, but plenty of fans out there are also dubbing the 49ers the best team overall after improving to 5-0 by taking down the defending Super Bowl champion Seattle Seahawks on the road. So, it’s no surprise that we’ll be making NFL expert picks with them as significant home favorites.

With that in mind, we’ve already got our overall Commanders vs. 49ers prediction for you, and when it comes to adding to our NFL best bets for Monday Night Football, we’re going to see some good-on-good action. Both of these teams have top-10 defensive line units when it comes to pass rush win rate!

That said, they also both have top-10 offensive line units when it comes to pass-block win rate, so something's got to give. What that is will help us lock in another one of our NFL best bets for Monday Night Football Week 6!

 

 

 

🏉 Commanders vs. 49ers Best Bet for NFL Week 6 MNF: Christian McCaffrey Over 58.5 Yards (-115 at DraftKings)

All the talk is about Brock Purdy right now given the latest MVP odds, but our target is arguably the chalkiest name to go with in this game. It makes sense given the pass rush rankings we just shared, but there is also a bit more to it. On the surface, it would indeed be Purdy who would headline a ton of NFL best bets for Monday Night Football.

Given how Mike Evans looked against the Seahawks, there’s nothing wrong with that at all. After all, Washington has allowed the fourth-most passing yards per game, while their rushing numbers haven’t been awful at all. However, we expect some serious regression in that department, as their run block win rate ranks 21st.

Their run block win rate also ranks dead last in the league, while San Francisco ranks fourth in that regard, hence our NFL best bets for Monday Night Football. The combination of that with a superstar RB makes this a play, and likely a popular one at that. Similarly, as big favorites, that supports a heavy dosage of the ground game.

Given the shootout with Seattle, we didn’t see quite as much volume, but we expect that to change here. Therefore, we’re going to add to our NFL best bets for Monday Night Football with Christian McCaffrey over 58.5 rushing yards (-115 at DraftKings).

🔢 Best NFL Player Prop Bets & Picks Today for Monday Night Football

The ways to make NFL predictions for MNF are all but endless, so we’ve also shared some of the most popular Commanders vs. 49ers player props for MNF at DraftKings Sportsbook:

Anytime Touchdown:

Passing Yards (Over/Under):

Rushing Yards (Over/Under):

Receiving Yards (Over/Under):

 

 

 

📊 Fantasy Alarm NFL Best Bets Record 

In case you haven’t been keeping tabs on our NFL picks all season, we’ve got you covered there as well - here’s our team’s current record:

  • Overall record: 115-83
  • Units: +26.88u
  • ROI: +13.18%

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