Clearly, the NFL schedule makers expected Bryce Young to take a big step in their rebuild this season by featuring them on Monday Night Football against the San Francisco 49ers. While it may not be of NFC Championship Game potential, it’s a Christian McCaffrey bowl, and we’ve added to it with our NFL best bets for Monday Night Football.

Additionally, you’ll find that you can add to any of your NFL picks, not just NFL predictions for MNF with a guaranteed two-part Sleeper Fantasy promo code bonus!

NFL Picks, Predictions & Best Bets for Monday Night Football, 11/24

Ok, perhaps we opened things up a bit harshly regarding the Panthers. After all, they do have a winning record and are just half a game behind the Tampa Bay Buccaneers in the NFC South. That said, if they were in the NFC West like the 49ers, there would be three teams sitting above them.

So, while Carolina very well may have their eyes set on the postseason, we wouldn’t put them on the same tier as San Francisco. With that in mind, where should we focus our NFL best bets for Monday Night Football? We see the 49ers as favorites of a touchdown, and we will undoubtedly want to check out some CMC props.

When these teams last met, Christian McCaffrey found the endzone as he often does. However, it was while wearing black and blue. His Panthers, at the time, lost to the 49ers 37-15. That was back in 2022, so much more than the CMC trade has happened since then, so we won’t make that the main focus of any NFL best bets for Monday Night Football.

 

 

 

Monday Night Football Prediction for Panthers vs. 49ers

Like the oddsmakers suggest, we too expect a win in prime time for the home team. To show them some love, Carolina QB Bryce Young is coming off his best game as a pro (448 passing yards, three TDs, and no INTs), and the emergence of Rico Dowdle and rookie WR Tetairoa McMillian simply cannot be ignored.

Even with that being the case, we picked on the Panthers' defense for our NFL best bets last week with Bijan Robinson 2+ TDs at +450 odds, and he came through. Admittedly, we don’t have a top pick from our NFL best bets for Monday Night Football this week lined up with such juicy odds, but we still love the spot.

Having given Bryce Young some love, let’s not forget that San Fran QB Brock Purdy also made his return after missing six games. He did so by leading his 49ers to a smooth 41-22 road victory over the Arizona Cardinals with three passing TDs. Of course, Christian McCaffrey’s three total TDs didn’t hurt either.

He’s sure to be the target of many NFL best bets for Monday Night Football, but let’s get into our absolute favorite pick.

 

 

 

Panthers vs. 49ers Best Bet for NFL Week 12: Brock Purdy Over 245.5 Passing Yards (Use His Sleeper Card)

If you want to go ahead and pick on Carolina’s run defense with your NFL picks MNF, we certainly won’t fault you - they rank 31st in run stop win rate. In fact, with the CMC revenge factor, that’s likely to be the most common approach this week. Oddsmakers know that as well, so our MNF NFL predictions are focused elsewhere.

As you can see, our top pick is still focused on the 49ers' side of the game. As much as the Panthers' run game can be exploited, so can their pass game. With the NFL’s fifth-worst defensive EPA per pass, you could argue that it’s even worse, hence our NFL best bets for Monday Night Football.

Mac Jones filled in admirably for Brock Purdy, and although we mentioned Purdy’s three passing TDs on Sunday, he didn’t exactly light it up yards-wise. His 200 paled in comparison to his first two games this season, when he threw for 277 and 209 yards. The only hesitation we could see here would be Kyle Shanahan's game planning for CMC to get his revenge.

That’s just fine by us - Christian McCaffrey also leads the team in receiving yards (732)! Along with a healthy George Kittle, Jauan Jennings and Ricky Pearsall, we’ve got Brock Purdy over 245.5 passing yards (use his Sleeper card) as the top pick from our NFL best bets for Monday Night Football.

 

 

 

Top NFL Player Props & Picks for Monday Night Football, 11/24

NFL picks for MNF using player projections are ideal at Sleeper Fantasy, and before we dive into their welcome offer, here are some popular Panthers vs. 49ers player props for MNF to consider for even more NFL predictions this week:

Passing Yards:

Rushing Yards:

Receiving Yards:

Anytime TD Scorer: 

 

 

 

How To Make Week 12 Monday Night Football Picks At Sleeper Fantasy & Claim Your $120 Bonus w/ Code ALARM

You’re more than welcome to fade or follow our NFL best bets for Monday Night Football, but whatever you want to go with, do so after claiming a guaranteed two-part Sleeper Fantasy promo code bonus:

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As you can see, you’ll be able to submit up to $120 worth lineups on the house, and you can use player projections from any sport, not just NFL picks! Explore everything that’s available to you by activating our exclusive Sleeper MNF promo code ALARM through this link!

 

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