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  1. 🎯 New to PrizePicks? Grab Your Bonus First
  2. Steven Matz PrizePicks MLB Pick — More 5.5 Strikeouts
  3. Randy Vasquez PrizePicks MLB Pick — More 4.5 Strikeouts
  4. Stack These Picks Today

Looking for the best PrizePicks MLB picks today? Fantasy Alarm breaks down every angle of Tuesday's slate so you can build your best Power Play or Flex entry with confidence. Check out Fantasy Alarm's PrizePicks MLB picks page for projections and expert breakdowns all season long. Here are the top PrizePicks MLB picks for Tuesday, April 21, 2026.

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Steven Matz PrizePicks MLB Pick — More 5.5 Strikeouts

Matz has quietly been one of the better stories in the AL rotation to start 2026. He is 3-0 with a 3.80 ERA and 21 strikeouts across 21.1 innings, and after a rough debut, he has put up a 2.76 ERA and 19 strikeouts over his last three starts combined. Today, he gets his second home start of the season at pitcher-friendly Tropicana Field, which only helps the case.

His 8.9 K/9 and 24.7 percent strikeout rate set a solid baseline, and the Cincinnati matchup is the right one to push that number higher. The Reds post a 27.2 percent strikeout rate against left-handed pitching, one of the highest marks in the National League. Matz's changeup is his best weapon against right-handed hitters, and Cincinnati's lineup features multiple right-handed bats who will be dealing with that offering all night. He is throwing strikes at a high rate and has not allowed more than two runs in any start this season. More 5.5 Strikeouts at home against a team punching out at a 27.2 percent clip against lefties is the play.

Randy Vasquez PrizePicks MLB Pick — More 4.5 Strikeouts

Vasquez has been one of the most pleasant surprises of the 2026 season, posting a 2.49 ERA with 19 strikeouts in his first three starts. His 10.4 K/9 and 27.8 percent strikeout rate represent a massive leap from his previous seasons and are backed by legitimate velocity gains that have made his entire arsenal more effective.

Today, he makes his second start of the season against Colorado, having already struck out eight Rockies in 5.2 innings earlier this month. He is 3-1 with a 3.86 ERA in seven career starts against them and knows this matchup well. The Rockies come in with a 25.4 percent strikeout rate against right-handed pitching, a lineup that has been one of the most strikeout-prone in the National League all season. With a pitcher in this kind of form against an opponent he has dominated, More 4.5 Strikeouts is a number Vasquez has already cleared once against this exact lineup this year.

 

 

 

Stack These Picks Today

Matz at Tropicana against a Reds lineup with a 27.2 percent strikeout rate vs lefties, and Vasquez at Coors against a Rockies offense he struck out eight times just twelve days ago. Two clean strikeout plays for Tuesday. Sign up with promo code ALARM and claim your guaranteed $50 bonus before first pitch.