Looking for the best PrizePicks MLB picks today? Our experts at Fantasy Alarm break down Saturday's top pitcher projections for the MLB slate, identifying the highest-value PrizePicks MLB entries across earned runs and outs recorded. Whether you're building a Power Play or a Flex entry, we've done the research so you don't have to. Check out Fantasy Alarm's PrizePicks MLB picks page for daily projections, lineup advice, and sharp analysis all season long.

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Lance McCullers PrizePicks MLB Pick — More 15.5 Outs

Lance McCullers showed in his 2026 season debut that when he is healthy and his command is dialed in, he has the ability to pitch deep into games, and the Mariners present an ideal matchup for him to do exactly that today.

McCullers delivered a dominant performance in his 2026 debut against the Boston Red Sox, striking out nine and allowing just one earned run across seven innings, recording 21 outs. That outing established that a healthy McCullers is capable of working well past the 15.5-out mark when his curveball is generating weak contact. The matchup today against Seattle gives him every reason to replicate that kind of performance. The Mariners have been one of the most punchless lineups against right-handed pitching in the early 2026 season, batting just .200 with a .664 OPS and a 27.6 percent strikeout rate against RHP. 

That combination of a low average, elevated strikeout rate, and suppressed OPS reflects a lineup that is giving away outs at a high rate and creating very few multi-base-hit threats for a pitcher to navigate.

Jacob Lopez PrizePicks MLB Pick — More 2.5 Earned Runs

Jacob Lopez has not made it through a start this season without allowing at least three earned runs, and the underlying numbers behind his early-2026 struggles give no reason to expect that to change today.

Lopez is sitting on a 6.48 ERA through two starts in 2026 with a 2.75 WHIP that is among the worst in the league. His control has been the central issue. He walked five batters in four innings against the Atlanta Braves in his season debut and followed that with five more walks in 4 1/3 innings against Houston on April 5, allowing three earned runs in each outing. Both starts cleared More 2.5 with ease. The walks are the critical factor here. When a pitcher is issuing five free passes per start, base runners accumulate quickly and inherited runner situations become unavoidable regardless of how the underlying contact plays out. 

More 2.5 Earned Runs for a pitcher carrying a 6.48 ERA and 2.75 WHIP who has cleared this number in both of his 2026 appearances is one of the most straightforward More selections on Saturday's board.

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