As the MLB postseason heats up, PrizePicks offers an exciting opportunity for DFS players to capitalize on player performances with its unique prop-based format. On October 6, 2025, the playoff action delivers a slate of high-stakes matchups, and our top DFS projections are here to guide your picks. From power hitters poised for big moments to pitchers ready to dominate, we’ve analyzed the stats, matchups, and trends to highlight the best PrizePicks selections for today’s games. Dive into our expert insights to optimize your lineup and maximize your winning potential!

 

 

PrizePicks MLB DFS Picks Today: Monday, 10/6; MLB DFS Projections

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Shohei Ohtani PrizePicks MLB Pick: More Than 0.5 Runs Scored

Shohei Ohtani, arguably the game’s premier talent, could kick off tonight’s matchup with a leadoff homer, instantly cashing this play. He crossed the plate in both of the Dodgers’ games against the Reds this postseason, and despite a scoreless Game 1 against the Phillies, Ohtani’s odds of scoring remain high. After racking up 146 runs during the regular season, the table is set for him to find home plate again on October 6, 2025.

 

 

 

Jesus Luzardo PrizePicks MLB Pick: Less Than 30.5 Fantasy Points

Jesus Luzardo’s 2025 season was a rollercoaster, with flashes of dominance marred by periods of inconsistency, struggling to locate pitches or generate swings and misses. In his last outing against the Dodgers, he surrendered four earned runs, managing just 27 fantasy points. With the high stakes of the postseason on October 6, 2025, Luzardo faces a quick hook if he falters early against a potent Dodgers lineup. Expect Los Angeles’ offense, particularly their lefty-mashing hitters, to capitalize and drive up the score tonight.

 

 

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