MLB Home Run Picks Today: Best HR Predictions for April 25th, 2026
It’s safe to say that we got to enjoy some Friday night fireworks to kick off our weekend with teams wasting no time to go yard. So, why not enjoy even more MLB home run picks for today? After all, we’ve got plenty of afternoon baseball to enjoy as well! So, we’ll even hook you up with our best MLB home run parlay for today!
You’ll also want to check out the best fantasy sports promo codes from the top legal sites in your state. Make sure that you also crush your MLB DFS contests today with our DFS Playbook, Starting Lineups, Lineup Generator & DFS Tools!
⚾ Top MLB Home Run Picks for Today
We were big on the action in Cincinnati yesterday, and even with the weather delay, we saw several dingers in the 17-run game. While they didn’t cash our MLB home run predictions, we were able to hit some MLB expert picks with Yankees vs. Astros and plenty of other games.
Of course, this is all about our best MLB home run picks for today, and if you just want those names ASAP, here you go:
- Manny Machado: +245 at Novig Sportsbook
- Nolan Arenado: +310 at FanDuel Sportsbook
- Andy Pages: +500 at bet365 Sportsbook
🔥 Best Matchups for Home Runs Today, 4/25: Ballpark Factors & Weather Impact
We were big on the Tigers vs. Reds game with it being at the Great American Ball Park, and stadiums certainly play a role in locking in the best targets. So too does checking in with our MLB weather report and more obvious factors like pitcher vs. hitter matchups. Therefore, we’ve shared more info as to why the guys above are our best MLB home run picks for today.
Manny Machado (+245)
If you saw the 15.5 total for Padres vs. Diamondbacks today and thought it was a line error, we’re confident that you weren’t alone. However, it’s very real, so it’s no surprise that we’re looking at that matchup. With both teams having great targets for our MLB home run picks, we’ll get one from each side for you.
Let’s start with San Diego going against Arizona starter Zac Gallen. Surprisingly enough, there are THREE Padres alone with shorter odds than Machado, so believe it or not, we’re actually giving you more value than it may seem. San Diego just put up 10 runs last night with two homers and Machado’s two hits.
That was at Coors Field, and this Mexico City game is clearly expected to be even more hitter-friendly, so let’s start our best MLB home run picks for today with Manny Machado to hit a HR (+245 at Novig).
Nolan Arenado (+310)
The same can be said here, as Arenado has a few teammates with even shorter odds than him to go yard today. Either way, we love this one even more with the veteran facing German Marquez. He’s a starter who has allowed his fair share of MLB home run picks at the aforementioned Coors Field when he was with the Colorado Rockies.
He’s another reason for the colossal game total, so frankly, we expect a few Arizona hitters to hit bombs today. Arenado is a former Colorado man himself and has four homers on the season thus far. Three of those have come against righties this season to help him establish a .443 slugging percentage.
Of course, the hitter-friendly location remains the same, so let’s add to our best MLB home run picks for today with Nolan Arenado to hit a HR (+310 at FanDuel).
Andy Pages (+500)
Ok, we need to switch things up from the NL West rivalry today, and for that, we’re heading to Dodger Stadium. It’s yet another hitter-friendly ballpark, especially given the winds blowing out today. While the location is a common one, the guy that we’re targeting with our MLB home run picks is not the one you’d expect.
When it comes to LA, it’s all about Shohei Ohtani, Freddie Freeman and the like (Mookie Betts is on the IL right now). So, let’s get better value here with Pages, who is actually tied for homers with Ohtani (5) and has more than Freeman (3). He also had two in just six games against the Cubs last season.
Against Chicago starter Colin Rea today, we’re wrapping up our best MLB home run picks for today with Andy Pages to hit a HR (+500 at bet365).
🚀 Longshot Home Run Picks Today
Still looking for more? No problem - we’ve also got you covered with our best MLB home run longshot pick for today!
You just saw a Dodger that provides more value than the “square” targets, so it’s only fitting to use LA for this spot as well. We’re getting four-figure odds with the great hitting conditions as they look to bounce back from last night’s loss. So, Kim is our best MLB home run longshot pick for today!
💲 Today’s Best MLB Home Run Parlay
Now that you’ve got the info as to why we went with our top MLB home run predictions today and a longshot pick, let’s wrap things up with the juiciest odds of all. After all, what would a Saturday be without a monster play to root for? Here’s our best MLB home run parlay for today:
- Machado, Arenado & Pages: +8230 at DraftKings, so a $10 bet pays $833!
We’ve got first pitches starting in the blink of an eye, so lock in all of the above, the one that sounds best to you or something in between. No matter your approach, let’s have these MLB home run picks make it the best weekend of the season yet!
Player News
{{item.text}}
{{analysis.analysis}}
