MLB Home Run Picks Today: Best HR Predictions for April 22nd, 2026
It’s been the Atlanta Braves both winning on the diamond more often than not and cashing some MLB home run picks for us these days, and with a full Wednesday slate on deck, we’re right back to hook you up with more! Whether Matt Olson and company make the cut or not, we’ll also share how to use our top spots to make the best MLB home run parlay for today!
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⚾ Top MLB Home Run Picks for Today
Unlike yesterday’s slate, we’ve got several afternoon matchups to enjoy. Therefore, before we fully break down each of our best MLB home run picks for today as an awesome way to add to our MLB expert picks, if you just want the names now, here you go:
- Bobby Witt, Jr.: +423 at DraftKings Sportsbook
- Jackson Merrill: +390 at FanDuel Sportsbook
- Ian Happ: +460 at Novig Sportsbook
🔥 Best Matchups for Home Runs Today, 4/22: Ballpark Factors & Weather Impact
When it comes to making MLB home run predictions, there are plenty of things to consider. The obvious is the hitters themselves, but we also always check out our MLB weather report, pitching matchups, and even the odds themselves to see if the prices are worth it. So, let’s dive deeper into our best MLB home run picks for today.
Bobby Witt Jr. (+423)
The first guy we talked about yesterday was Bryce Harper, and he went yard for us! That means we’ve hit one of our MLB home run picks in back-to-back days, and we’re looking to keep the good times rolling, starting with Bobby Witt, Jr. You’re telling us that the young stud still hasn’t hit one this year? Today’s the day.
He and the Kansas City Royals are facing Chris Bassitt, who strikes out hitters so rarely that his K prop is just 3.5! Despite Witt still looking for his first dinger, he has the shortest odds of any Royals hitter, even with Carter Jensen having already hit five of them. In other words, there is no reason to panic.
Along with double-digit winds blowing out, let’s start our best MLB home run picks for today with Bobby Witt, Jr. to hit a HR (+423 at DraftKings).
Jackson Merrill (+390)
Somehow, there was a 1-0 game at Coors Field last night, so you know either Manny Machado or Fernando Tatis, Jr. will hit one since they didn’t come through for us. So, feel free to go with those big names instead, but we’ll switch things up for you with our MLB home run picks in case you want some variety.
In that regard, we’re going to put our coin on Jackson Merrill going against Colorado starter Tomoyuki Sugano. He’s a lefty with a good matchup that has three homers so far this year and had the fourth-most on the team last season, albeit still not a ton. Even still, Coors Field’s thin air speaks for itself, AND we have 20+ mph winds today!
The location makes it a “square” play, but we’re still adding to our best MLB home run picks for today with Jackson Merrill to hit a HR (+390 at FanDuel).
Ian Happ (+460)
This one is a bit of a pick special for us specifically, as it’s the Phillies vs. Cubs matchup. Again, Harper cashed for us last night, and when we targeted Happ last week, we cashed with him as well! So, why not make him part of our top MLB home run picks today? After all, he gets to face Philly starter Kyle Backhus.
He’s an inexperienced reliever set to open the game, and this is a slugger who’s already hit six homers this season. Our other pick here would be Dansby Swanson, but they can both absolutely get the job done. We like all the Cubs action today, but we’ll officially add to our best MLB home run picks for today with Ian Happ to hit a HR (+460 at Novig).
🚀 Longshot Home Run Picks Today
Before we piece things together for unbelievable odds, we also want to share our MLB home run longshot pick for today!
Nationals Park has been a hitter’s paradise far more often than not, including Drake Baldwin and James Wood going yard last night. Jacob Young had two RBI to boot, so with these juicy odds, we’re going to make him our best MLB home run longshot pick for today.
💲 Today’s Best MLB Home Run Parlay
As promised, let’s piece our MLB home run predictions together. While individual plays provide great payouts to begin with, why not really add some thrill to your Wednesday? Here’s our best MLB home run parlay for today:
- Witt, Jr., Merrill & Happ: +14309 at DraftKings, so a $10 bet pays $1,440.96!
No matter how you decide to use our MLB home run picks, let’s make it the best day of the seemingly never-ending season yet!
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